| The healing of chronic skin wound, a complicated but orderly pathophysiolological process involved many factors
such as inflammatory cell and cytokin and related to issue repair, regeneration and reconstruction, is still an important and hot spot in
clinic research. With the development of molecular biology, we have a futher understanding about the mechanism of the wound healing.
Wnt signaling pathway is a highly conserved pathway consisted of Wnt protein, receptor and regulatory protein, and participate in many
process such as cell proliferation, apoptosis, differentiation. As a pathway involved in wound healing, Wnt signaling is considered to
regulate and induce the development of skin, appendage and follicles, promote the angiogenesis of wound and epithelia remodeling. By
reviewing the literature, we try to reveal the relationship between Wnt signaling pathway and skin wound healing from inflammatory
cells, fibroblasts, stemcell, angiogenesis, epidermis and hair follicle regeneration and so on. |
