| Objective:To explore the inhibitory effect of Matrine combined cisplatin on murine cervical cancer by U14 xenograft.Methods:Cervical cancer transplantation tumor model in mice was perpetrated, all mice were randomly divided into 8 groups: matrine
groups( high, mediumand low dose group), cisplatin plus bitter and alkali groups(high, medium and low dose group), cisplatin group and
control group. After treatment, tumor inhibition rate,thymus index, spleen index, creatinine and urea nitrogen levels were calculated.Results:(1) Compared with the control group, tumor weight of other groups were reduced, in the cisplatin group, the matrine high-dose
group and combination group, tumor weight decreased obviously, the difference was statistically significant(P<0.01). (2)Compared with
control group, the thymus index and spleen index of cisplatin group decreased significantly (P<0.01), compared with the control group
and cisplatin group, thymus index and spleen index of matrine and combined cisplatin group increased significantly, with significant
differences(P<0.01). (3) Compared with cisplatin group, creatinine and urea nitrogen values of high dose combination group decreased
significantly (P<0.01), values for medium dose combination group also decreased (P<0.05), but no significant decrease was observed in
low dose group (P>0.05).Conclusion:A certain concentration of bitter and alkali has inhibitory effect on murine cervical cancer of U14
xenograft. When combined in treatment, it can enhance the anti-tumor effect of cisplatin, and reduce the side effects of the cisplatin, the
immunity can be also promoted as well. |
