范公忍 李树玲 郑海燕 王文欢 曹建彪.骨髓干细胞移植治疗肝硬化的基础与临床研究现状[J].现代生物医学进展英文版,2015,15(10):1957-1962. |
骨髓干细胞移植治疗肝硬化的基础与临床研究现状 |
Basic and Clinical Research of Bone Marrow StemCells in Treatmentof Hepatic Cirrhosis |
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DOI: |
中文关键词: 骨髓干细胞 肝硬化 移植 |
英文关键词: Bone marrow stemcells Liver cirrhosis Transplantation |
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中文摘要: |
肝硬化是一种临床常见的肝病良性终末期表现。目前临床上尚缺乏有效的治疗措施。肝脏移植是最理想的治疗方法,但受
供体肝脏来源限制,且费用昂贵。近年来开展的自体骨髓干细胞(BMSCs)移植治疗,为肝硬化的治疗带来了新的希望。BMSCs主
要包括造型血干细胞和间充质干细胞,其具有可塑性,体外通过生长因子,体内利用特定微环境均可诱导BMSCs 分化为肝前体
细胞和成熟肝细胞,并明显改善肝功能。从动物实验到临床研究亦表明,BMSCs 具有来源丰富、费用低廉、损伤小、自体移植不栓
塞、无排斥反应等优点,为治疗肝病带来了新思路,有望成为生物人工肝的细胞来源。本文就BMSCs 移植治疗肝硬化的研究现状,
尤其是移植途径以及在肝脏内定居、迁移和分化机制的示踪观察方法和存在的问题作一综述,以期为从事肝病研究的同仁提供
参考依据。通过对BMSCs移植从基础研究及临床应用的最新进展的描述,展示BMSCs 在肝硬化治疗方面良好的治疗前景。 |
英文摘要: |
Liver cirrhosis is a common benign end-stage liver disease shorting clinical effective treatment measures. Liver
transplantation is the optimal treatment method, but with the limitation of donor liver source and high-cost. In recent years, the
development of auto-logous bone marrow stem cells (BMSCs) transplantation has brought new hope for the treatment of liver cirrhosis.
BMSCs include mesenchymal stem cells and hemopeietic stem cells, which are characterized by plasticity. Growth factors in vitro and
special microenvironment in vivocouuld induce the differentiation of bone marrow stem cells into the precursor of hepatocytes and
mature hepatocytes. Moreover, hepatic function could be improved obviously. The superiorities of bone marrow stem cells included
affluent source, low cost, little injury, without embolism and graft rejection in autologous transplantation, which offere a new style for
curing hepatic diseases. bone marrow stem cells would be the cell resource of artificial liver. In this paper, the research status of BMSCs
transplantation for the treatment of liver cirrhosis, especially the ways of liver transplantation and the tracing method of BMSCs
settlement, migration and differentiation mechanism in liver and existing problems are reviewed, expecting to provide reference for
colleagues engaged in the study of liver diseases. Basic and clinical research about bone marrow stem cells transplantation indicate that
bone marrow stemcells transplantation has a broad prospect in the treatment of hepatic cirrhosis. |
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