| Objective:To investigate the clinical effect of glucosamine hydrochloride combined with non-steroidal antiinflammatory
drug in the treatment of patients with moderate knee osteoarthritis.Methods:A total of 214 patients with moderate knee
osteoarthritis, who were treated in Panzhihua Central Hospital of Sichuan Province from May 2010 to September 2013, were randomly
divided into experiment group (107 cases) and control group (107 cases). The control group was only given glucosamine hydrochloride,
while the experiment group was given glucosamine hydrochloride combined with non-steroidal anti-inflammatory drug. The Lequesne
score, treatment effect and adverse reaction 2, 4, 8, 12 weeks after treatment were compared between the two groups.Results:Before
treatment, there was no statistically significant difference in Lequesne score between the two groups (P>0.05). But after treatment,
Lequesne scores of 2, 4, 8, 12 weeks in the experiment group were all lower than those of the control group, the difference was
statistically significant (P<0.05), and Lequesne scores of the two groups reached the minimum 2, 4 weeks after treatment. The effective
rate of the two groups decreased 12 weeks after treatment, but the effective rate of experiment group was higher than that of control
group 2, 4, 8, 12 weeks after treatment, the difference was statistically significant (P<0.05), and the effective rate of the two groups 2, 4
weeks after treatment reached the highest. The adverse reaction rate (6.54%) of experiment group was significantly higher than that
(3.74%) of control group, and the difference was not statistically significant (P>0.05).Conclusion:Glucosamine hydrochloride combined
with non-steroidal anti- inflammatory drug has better short-term efficacy in the treatment of patients with moderate knee osteoarthritis,
but it has many side effects in long-termtherapy, so it is suggested that this therapy should be used within 2-4 weeks in clinical treatment. |
