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目的：观察自体骨髓间充质干细胞(BMSC)移植治疗合并不同并发症的失代偿期肝硬化的临床效果。方法：回顾性分析我院自2008 年12月至2013 年12 月收治的148 例经自体BMSC 移植治疗的肝硬化合并肝性脑病、肝肾综合征、肝源性糖尿病以及消化道出血患者治疗前后的肝、肾功能、血清蛋白、血常规等指标的变化情况。结果：治疗后，肝硬化合并肝性脑病患者的ALT、血氨水平改善明显，TBIL 反复；合并肝肾综合征的患者HB、Crea 水平改善明显，ALT、AST、DBIL 反复；合并肝源性糖尿病患者的 ALT、TBIL、DBIL、TB、ALB、血糖水平改善明显；合并消化道出血患者的ALT、TP、ALB 改善明显，AST、TBIL、PLT 反复。结论：自体BMSC 移植治疗肝硬化合并肝源性糖尿病的效果较好，对合并肝性脑病、肝肾综合征以及消化道出血患者的效果欠佳。

英文摘要:

Objective:To observe the clinical effect of autologous bone marrow mesenchymal stem cells (BMSC) transplantation in the treatment of decompensated cirrhosis combined with different complications.Methods:The changes of liver and renal function, serum protein, blood routine index before and after the treatment of 148 cases of cirrhotic patients with hepatic encephalopathy, hepatorenal syndrome, hepatic diabetes and digestive tract hemorrhage admitted from 2008 December to 2013 December in our hospital and treated by autologous BMSCs were retrospectively analyzed.Results:After treatment, the serum ALT, blood ammonia levels of cirrhosis patients combined with hepatic encephalopathy improved significantly, but the serum TBIL level changed repeatedly; the serum HB, Crea levels of cirrhosis patients combined with hepatorenal syndrome improved significantly, but the serum ALT, AST, DBIL levels changed repeatedly; the serum ALT, TBIL, DBIL, TB, ALB, blood sugar levels of cirrhosis patients combined with hepatogenic diabetes improved significantly; the serum ALT, TP, ALB levels of cirrhosis patients combined with hemorrhage of digestive tract improved significantly, but the serum AST, TBIL, PLT levels changed repeatedly.Conclusion:Autologous BMSCs transplantation had excellent efficacy in the treatment of hepatic cirrhosis combined with diabetes, but the clinical effect on cirrhosis patients combined with hepatic encephalopathy, hepatorenal syndrome and digestive tract hemorrhage were not good enough.

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