| 张铁龙 董文培 刘强 李涛 梁军号△.一个以前列腺特异抗原密度和穿刺评分为基础的中国人群中前列腺癌根治术后病理升级预测模型的建立[J].现代生物医学进展英文版,2015,15(10):1805-1808. |
| 一个以前列腺特异抗原密度和穿刺评分为基础的中国人群中前列腺癌根治术后病理升级预测模型的建立 |
| Establishment ofA Predictive Model for the Pathologic Upgrade afterRadical Prostatectomy based on the Prostate Specific Antigen Density andBiopsy Gleason Score in Chinese Population |
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| DOI： |
| 中文关键词: 前列腺癌 Gleason 评分 病理升级 诺模图 |
| 英文关键词: Prostate cancer Gleason score Pathological upgrading Nomogram |
| 基金项目: |
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| 中文摘要: |
| 目的：分析前列腺癌根治术后病理得分较穿刺得分增加的原因，并建立一个可以预测中国人群中前列腺癌根治术后病理升
级的模型。方法：以2008 年8 月至2013 年12 月在我院泌尿科行前列腺癌根治性切除术的264例患者的临床资料为基础，根据
术前和术后患者病理得分的变化将其分为升级组和未升级组。运用单因素和多因素logistic 回归分析病理升级的原因，并通过多
因素回归系数建立预测病理升级的诺模图。结果：264 例患者中，共238 例最终纳入统计分析，多因素logistic 回归分析显示前列
腺特异抗原密度(0R=3.854，P=0.001 )和穿刺Gleason(≤ 6)评分是中国人群中前列腺癌根治术后病理升级的独立危险因素。前列腺
特异抗原密度和穿刺得分的ROC 最佳截断取值为0.37 ng/ml 2和8 分。运用上述两个变量建立了一个可用于预测病理升级的诺
模图。结论：前列腺特异抗原密度和穿刺Gleason 评分是预测中国人群中前列腺癌根治术后病理升级的独立危险因素，本研究所
得的诺模图可以很好地预测前列腺癌根治术后的病理升级。 |
| 英文摘要: |
| Objective:To analyze the reason of upgrade in Gleason score between initial prostate biopsy and final radical
prostatectomy specimens and develop a nomogram to predict the probability of pathological upgrade.Methods:From August 2008 to
December 2013, a total of 264 prostate cancer patients underwent RP in our department were selected and divided into two groups
according to the upgrade of biopsy and final pathology GS. Both a univariate analysis and a Forward conditional multivariate logistic
regression model (LRM) analysis were performed to identify the risk factor (s) of pathological upgrade. A nomogram predicting the
probability of pathological upgrade was established by using LRM regression coefficients.Results:In total, 238 of the 264 patients were
analyzed. Multivariate logistic regression analysis showed that higher prostate specific antigen density(PSAD) (0R=3.854, P=0.001) and
low grade (≤ 6) biopsy GS were. The dependent risk factors of the pathological upgrade after radical prostatectomy. The optimal cutoff
value of PASD and biopsy score were 0.37 ng/ml 2 and 8 points. A nomogram combining aforementioned two variables to predict
pathological upgrading was established.Conclusion:PASD and biopsy Gleason score were independent risk factors for predicting the
postoperative pathological upgrade in Chinese population, the nomogram established in the study could well predict the pathological
upgrade. |
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