| 陈翔 周志斐 刘芬 苏惠玲 张翼.尼古丁对全身及口腔牙周组织的病理作用研究[J].现代生物医学进展英文版,2015,15(9):1778-1780. |
| 尼古丁对全身及口腔牙周组织的病理作用研究 |
| Study on the Deteriorating Effect of Nicotine Toward the Systematicand Periodontal Tissues |
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| DOI： |
| 中文关键词: 尼古丁 系统性疾病 牙胚发育 牙周炎 alpha7 亚型乙酰胆碱受体 |
| 英文关键词: Nicotine Systematic disease Tooth development Periodontitis alpha7 nicotinic acetylcholine receptor |
| 基金项目: |
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| 中文摘要: |
| 在烟草的毒性物质中，尼古丁是主要成分。作为烟草的活性成分，尼古丁可对全身多系统产生病理性危害作用。除此以外，
进入母体血液中的尼古丁可对正在发育的胎儿产生影响。牙周炎是口腔常见病，是成人牙齿丧失的主要原因之一。吸烟是牙周炎
的重要危险因素。吸烟者较不吸烟者牙周炎的患病率高、病情重。大量研究表明：吸烟与牙周袋形成、附着丧失、骨丧失及牙齿丧
失有关。牙周炎的发生发展存在牙周组织破坏和再生修复两种相互交替的过程，而尼古丁对牙周炎的影响也在于加速牙周组织
破坏，抑制再生修复从而使得较之于非吸烟者而言，吸烟者的病情更加严重。同时，尚可使吸烟者经系统性牙周治疗的预后较差。
本文通过文献回顾，旨在探讨吸烟对多种全身系统性疾病的影响尤其是在牙周病发生发展过程中的可能作用。同时提出未来研
究的可能方向及临床应用。 |
| 英文摘要: |
| Nicotine is the well established toxic substance in cigarette. Besides its side effect toward many organs in the
performance of systematic disease, it could also deteriorate the development of infants. Periodontitis is a common seen disease in oral
system which has already been considered as a main reason of losing teeth for adults and cigarette smoking is a well established risk
factor in its etiology. Compared with normal control, smokers have a higher prevalence and a more severe condition in periodontitis
suffering. Published reports indicated that smoking has something to do with the formation of periodontal pocket, loss of periodontal
attachment and loss of bone volume and teeth. The effect of nicotine on periodontitis has two sides. For one thing it would increase the
susceptibility for smokers and accelerate the disease progress; for the other, the prognosis of a smoker is unsatisfactory even if he/she
receives systematic therapy and a worse regenerative of periodontal bony substance would be detected compared with non smokers. This
review aims to discuss the mechanismof the deteriorating effect of nicotine and provide some theoretical evidence for its research. |
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