| 高永涛 王俊 史建华 于净松 王岩.miR-451 与人类肿瘤关系的研究进展[J].现代生物医学进展英文版,2015,15(9):1769-1771. |
| miR-451 与人类肿瘤关系的研究进展 |
| The Research Progress of Relationship between miR-451and Human Tumor |
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| DOI： |
| 中文关键词: miR-451 肿瘤 基因调控 |
| 英文关键词: miR-451 Cancer Gene regulation |
| 基金项目:黑龙江省自然科学青年基金项目（QC2010010） |
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| 中文摘要: |
| MicroRNAs (miRNA)是一类在转录后水平调控基因表达的小分子非编码RNAs，通过调节细胞的增殖、分化、凋亡使机体维
一个动态平衡。近年来，大量研究表明许多miRNA可作为原癌基因或者抑癌基因参与肿瘤的发生、发展，进一步研究发现，通过
检测和调控这些miRNA，可用于肿瘤的早期诊断和治疗。最近一系列研究发现miRNA-451（miR-451）在许多肿瘤中存在差异性
表达，与这些肿瘤的发生、发展、治疗有着密切的联系。本文对人类肿瘤中miR-451 表达、调控的相关研究做一综述，为miR-451
在肿瘤的诊断、治疗及预后中的应用提供重要资料。 |
| 英文摘要: |
| MicroRNAs (miRNAs) are one kind of short non-coding RNAs that regulate gene expression at the post-transcription
level, and maintain a dynamic balance of body by regulating cell proliferation, differentiation, and apoptosis. Recently, a lot of studies
have revealed that some miRNAs are involved in the tumorigenesis and tumor progression as oncogenes or tumor suppressors. Further
studies showed that it can be used for the early diagnosis and therapy of cancer by detecting and/or regulating these miRNAs. Lot of
research indicated that the expression of miRNA-451 (miR-451) is non-identical in different tumors, and it may play a critical role in
tumorigenesis, tumor progression and tumor therapy. In this review, we summarize the relevant research about the expression and
regulation of miR-451 in various human tumors, and try to provide important information for cancer diagnosis, treatment and prognosis. |
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