| 谭平萍 邓亚平 钟晶敏 高妮娜 刘志红.S100A4 在子宫内膜癌中的表达及其临床病理意义[J].现代生物医学进展英文版,2015,15(9):1681-1684. |
| S100A4 在子宫内膜癌中的表达及其临床病理意义 |
| Expression and Clinicopathological Significance of S100A4 inEndometrial Cancer |
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| DOI： |
| 中文关键词: S100A4 诊断 预后预测 子宫内膜癌 |
| 英文关键词: S100A4 Diagnosis Prognostic prediction Endometrial Cancer |
| 基金项目:湖南省科学技术厅科技计划项目（2010FJ3154） |
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| 中文摘要: |
| 目的：检测S100A4 在子宫内膜癌中的表达并分析其与子宫内膜癌临床病理指标的相关性，为子宫内膜癌的临床诊断、治疗
及与预后预测提供参考依据。方法：采用免疫组织化学技术检测比较70 例子宫内膜癌和40 例正常子宫内膜组织中S100A4 的表
达，并分析子宫内膜癌组织中S100A4 的表达与患者临床病理指标和生存期的相关性。结果：70 例子宫内膜癌组织中S100A4 的
阳性表达率为57.14%(40/70)，40 例正常子宫内膜组织中S100A4 的阳性表达率为10%(4/40)，显著低于子宫内膜癌组织(P<0.05)。
子宫内膜癌组织中S100A4 的表达与患者的年龄和淋巴结转移无显著相关，但与肿块浸润子宫肌壁深度、分化程度、临床分期均
呈显著相关(P<0.05)。S100A4 呈阳性表达的子宫内膜癌患者的生存率和生存期均较S100A4 呈阴性表达病例显著降低或缩短
(P=0.01)。结论：子宫内膜癌组织中S100A4 呈异常高表达，与子宫内膜癌的发生发展和预后密切相关，可能作为子宫内膜癌诊断
和预后预测的参考标志物。 |
| 英文摘要: |
| Objective:The aim of this study was to detect the expression of S100A4 in endometrial cancer and analyze its
correlation with the clinicopathological features of endometrial cancer so as to provide references for the clinical diagnosis, treatment and
prognostic prediction of endometrial cancer.Methods:The expression of S100A4 was detected by immunohistochemistry in 70 cases of
endometrial carcinoma and 40 cases of normal endometrium, and the correlation of S100A4 expression with clinical pathology index and
survival was analyzed.Results:The positive rate of S100A4 expression in 70 cases of endometrial carcinoma tissues was 57.14%(40/70),
which was significantly higher than that in 40 cases of normal endometrial tissue (10%, P<0.05). The expression of S100A4 had no
significant correlation with the age and lymph node metastasis, but was significantly correlated with the tumor invasion depth of uterine
muscle wall, differentiation degree and clinical stage (P<0.05). The survival rate and survival time of endometrial cancer with S100A4
positive expression was markedly lower or shorter than those with S100A4 negative expression (P=0.01).Conclusion:Abnormal
upregulation of S100A4 expression was found in endometrial carcinoma and was closely related to the occurrence and prognostic
prediction of endometrial carcinoma. S100A4 may be used as a marker of the diagnosis and prognosis of endometrial cancer. |
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