| 傅庆萍 孙明忠 朱蓉 周中卫 金浩 居会祥.整合素alpha-v mRNA在食管鳞状细胞癌组织的表达研究[J].现代生物医学进展英文版,2015,15(9):1659-1662. |
| 整合素alpha-v mRNA在食管鳞状细胞癌组织的表达研究 |
| A Study on Expression of Integrin alpha-v mRNA in EsophagealSquamous Cell Carcinoma |
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| DOI： |
| 中文关键词: ITGAV 食管鳞状细胞 转移 |
| 英文关键词: ITGAV Esophageal squamous cell carcinoma Metastasis |
| 基金项目:盐城市科技局科技发展计划项目（YK2012055） |
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| 中文摘要: |
| 目的：检测食管鳞状细胞癌（Esophageal squamous cell carcinoma ESCC)组织整合素alpha-v（integrin alpha-v ITGA V)的表达，分析
ITGA V 表达与临床病理因素之间的相关性，探讨ITGA V在ESCC 的进展和预后中的作用。方法：采用实时荧光定量PCR法检
测72 例ESCC 组织ITGA V的表达，并同时检测33 例食管炎性组织为对照。分析ITGA V表达与ESCC癌临床病理因素之间的
相关性。结果：ESCC癌组织中ITGAV的mRNA表达水平明显高于炎症组织（P<0.05），且表达水平与T、N 和临床分期（P均<0.05）
呈显著相关，而与患者年龄及性别无相关性。结论：ITGA V 的过度表达与ESCC的转移、进展有关，ITGA V可能会成为ESCC 患
者个体化治疗有效的预后标志物。 |
| 英文摘要: |
| Objective:The study aimed to detect the integrin alpha-v (ITGA V) mRNA expression in Esophageal squamous cell
carcinoma (ESCC), and to evaluate the correlation between integrin alpha-v mRNA expression and clinicopathological factors.Methods:From 2012 to 2013, 72 cases of tissue samples of ESCC patients as the research object, and the 33 esophageal inflammation tissues as
control. Real-time PCR assay was performed to detect the expression of ITGA V in all tissue samples. The RT-PCR results were analyzed
and the correlation between ITGA V expression and clinicopathological factors was evaluated.Results:In ESCC patients’tissues, the
expression level of ITGA V mRNA was significantly higher than those in the inflammation tissues (P<0.05), and the expression level
were significantly correlated with T, N and clinical stage (all P<0.05).Conclusion:All these findings suggest that overexpression of
ITGA V is closely associated with metastasis and progression of ESCC. Therefore, we suppose that ITGA V could be an effective
prognostic marker in individualized treatment of patients with ESCC. |
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