| 李辉 王曙辰 李庆腊 宋玉文 刘晓谦.蛋白酪氨酸磷酸酶SHP-2与疾病的相关性研究进展[J].现代生物医学进展英文版,2015,15(8):1595-1597. |
| 蛋白酪氨酸磷酸酶SHP-2与疾病的相关性研究进展 |
| The Development of Protein-tyrosine Phosphatase SHP-2 and CorrelatedDiseases |
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| DOI： |
| 中文关键词: 蛋白酪氨酸磷酸酶 磷酸化 去磷酸化 疾病 |
| 英文关键词: Protein-Tyrosine Phosphatase Phosphorylation Dephosphorylation Disease |
| 基金项目:黑龙江省自然科学基金项目面上项目（D201140） |
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| 中文摘要: |
| 蛋白酪氨酸磷酸酶家族由130 多种蛋白酪氨酸磷酸酶组成，它们和蛋白质酪氨酸激酶家族一起调控蛋白质中酪氨酸残基
的磷酸化以及去磷酸化的动态平衡，它们的活性直接决定细胞内蛋白质的磷酸化水平的高低。SHP-2是蛋白酪氨酸磷酸酶家族的
一员，在各种细胞和组织中均有广泛的表达，参与多个信号传导通路，介导细胞的生长、分化、迁移、粘附及凋亡等。SHP-2 的表达
异常会导致多种疾病的产生，但是相关综述较少，同时未见文献报道其在胶质瘤中的作用，因此本文简要介绍SHP-2 的结构、功
能、信号传导，并阐述了SHP-2与常见疾病的关系。 |
| 英文摘要: |
| Protein-Tyrosine Phosphatase (PTPs) Family is constructed by more than 130 protein-tyrosine phosphatases, and
could work together with protein-tyrosine kinase to modulate of phosphorylation and dephosphorylation balancing of tyrosine residue of
proteins. Their activities affect the phosphorylation level of cellular proteins directly. SHP-2 is a member of PTPs Family, expressed
extensively in cells and tissues. SHP-2 is involved in several cell signal pathways, as well as inducing cell proliferation, differentiation,
migration, adhesion and apoptosis. The abnormality of SHP-2 would result in many disorders and disease, but the related review is is less.
At the same time, the literature that reported its role in the glioma has not been found. So this article reviewed the structure, functions,
cell signal transduction of SHP-2, as well as the diseases which are induced by SHP-2 dysfunction. |
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