| 孙光玲 孙伟 兰倩 陈莹莹 苏志强.鞘磷脂代谢与脑缺血[J].现代生物医学进展英文版,2015,15(8):1566-1569. |
| 鞘磷脂代谢与脑缺血 |
| The Sphingomyelin Metabolismof Cerebral Ischemia |
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| DOI： |
| 中文关键词: 1- 磷酸鞘氨醇 1-磷酸鞘氨醇受体 鞘氨醇激酶 脑缺血 |
| 英文关键词: Sphingosine 1-phosphase 1 - phosphate sphingosine receptor Sphingosine kinase Cerebral ischemia |
| 基金项目: |
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| 中文摘要: |
| 鞘磷脂特别是鞘脂是髓鞘的主要成分，高度集中在中枢神经系统。在生理和病理生理条件下，具有生物活性的鞘磷脂及其
代谢产物以及信号传导过程的重要性正在逐步被人们所认识。鞘脂代谢产物鞘氨醇及其前体物质神经酰胺与细胞生长停滞和凋
亡有关，而1 -磷酸鞘氨醇与增强细胞增殖、分化和细胞生存以及调节细胞的生理和病理过程有关，具有细胞外第一信使和细胞
内第二信使的双重功能。这三者之间的相互转换、鞘脂代谢物的相对水平以及细胞的命运，受到鞘氨醇激酶的活性的强烈影响。
鞘氨醇激酶可催化磷酸鞘氨醇产生1- 磷酸鞘氨醇。1- 磷酸鞘氨醇在中枢神经系统中与G蛋白偶联受体家族结合对中枢神经系
统发挥作用。本文对鞘磷脂代谢过程中的鞘氨醇激酶、1- 磷酸鞘氨醇及其受体与脑缺血之间的关系进行概述。 |
| 英文摘要: |
| Sphingomyelin especially sphingolipid is myelin sheath of the main composition, high concentration in the central
nervous system. In physiological and pathophysiological conditions,bioactive sphingomyelin and its metabolites and signaling the
importance of process is gradually known by people. While the sphingolipid metabolites sphingosine and its precursor ceramide have
been associated with cell growth arrest and apoptosis, sphingosine-1-phosphate (S1P) enhances proliferation, differentiation, and cell
survival as well as regulates many physiological and pathological processes. The relative levels of these three interconvertible
sphingolipid metabolites, and thus cell fate, are strongly influenced by the activity of sphingosine kinases.Sphingosine kinase (Sphk)
catalyze sphingosine phosphate generat S1P. S1P in the central nervous system, in combination with a G protein coupled receptor family
have an impact on the central nervous system.In this paper,the sphingomyelin metabolic process of sphingosine kinase, 1 - phosphate
sphingosine and its receptor and cerebral ischemia of the relationship between the overview. |
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