| 胡玉婷 党利君 马远方 金言.γδT细胞在肿瘤免疫治疗中的研究进展[J].现代生物医学进展英文版,2015,15(8):1562-1565. |
| γδT细胞在肿瘤免疫治疗中的研究进展 |
| Research Progress of γδT Cells in Cancer Immunotherapy |
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| DOI： |
| 中文关键词: γδT 细胞 细胞免疫治疗 肿瘤 |
| 英文关键词: γδT cell Immunotherapy Tumor |
| 基金项目: |
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| 中文摘要: |
| 癌症是威胁人类健康最主要的疾病之一，目前临床上主要采用的手术/ 放化疗联合治疗的疗效有限，因此如何进一步提高
肿瘤临床疗效仍是巨大的挑战。免疫细胞过继是肿瘤治疗技术中迅速发展的一种生物治疗技术，通过输入自身或同种"抗肿瘤免
疫效应细胞"达到直接杀伤肿瘤或增强机体自身细胞免疫功能的作用。由于γδT 细胞对肿瘤细胞具有强有力的直接细胞毒性，
并可与其他免疫细胞协同作用发挥其抗肿瘤活性，因而成为了细胞免疫治疗中新的研究热点。本文主要叙述了γδT 细胞与肿瘤
相关的基础研究及临床试验的最新进展。 |
| 英文摘要: |
| Cancer is the major threat to human health. Traditional treatment, which combines surgery with radiotherapy,
chemotherapy and other subsidiary treatments, still faces tremendous challenges to enhance the efficacy and lower the possibility of
cancer recurrence. Recently immunotherapy offers a promising option for cancer treatment which evokes broad interest. Innate immune
cells, in particular γδT cells, have become the promising candidates to be adoptively transferred, because of their strong anti-tumor
cytotoxicity and synergistic effect with other immune cells. This paper described the new progresses of the γδT cells in basic research
and clinical trials for cancer treatment. |
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