| 王银娜 王英 贾艳丽 孙懿 何悦明 王绿娅.维持性血液透析患者血清sTWEAK水平与冠状动脉钙化的相关性研究[J].现代生物医学进展英文版,2015,15(8):1514-1517. |
| 维持性血液透析患者血清sTWEAK水平与冠状动脉钙化的相关性研究 |
| Correlation of SerumsTWEAK Levels with Coronary Artery Calcification inMaintenance Hemodialysis Patients |
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| DOI： |
| 中文关键词: 血液透析 可溶性肿瘤坏死因子样凋亡微弱诱导剂 血管钙化 冠状动脉钙化 |
| 英文关键词: Hemodialysis sTWEAK Vascular calcification Coronary artery calcification |
| 基金项目:国家自然科学基金项目(81271923)；首都医科大学基础-临床科研合作基金（14JL68） |
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| 中文摘要: |
| 目的：探讨维持性血液透析患者血清可溶性肿瘤坏死因子样凋亡微弱诱导剂(sTWEAK)水平与冠状动脉钙化的关系。方法：
选择维持性血液透析患者60 例和健康对照组30 例，采用双抗体夹心酶联免疫吸附技术测定其血清sTWEAK 水平，采用多层螺
旋CT(MSCT)测定其冠状动脉钙化积分(CACs)，比较两组的血清sTWEAK水平、CACs，并分析二者的相关性及血液透析患者冠
状动脉钙化的危险因素。结果：血液透析患者血清sTWEAK 水平显著低于正常对照组，分别为186.23(148.35，220.74)pg/mL 和
265.13(210.91，298.22)pg/mL，差异有统计学意义(P＜0.01)。CACs>400 的血液透析患者血清sTWEAK水平显著高于CACs≤ 400
者，分别为220.73(189.70，251.67)pg/mL和146.07(138.43，180.11)pg/mL，差异有统计学意义(P＜0.01)。Spearman 等级相关分析显
示血液透析患者的血清sTWEAK水平与患者的CACs 呈明显正相关(r=0.482，P＜0.01)。多因素逐步回归分析显示影响血液透析
患者CACs 严重程度的因素有血清sTWEAK水平、年龄、透析龄、糖尿病(P＜0.05)。结论：维持性血液透析患者血清sTWEAK 水
平较正常人降低，但在血液透析患者sTWEAK 范围内，高水平的血清sTWEAK 水平与重度冠状动脉钙化相关；血清sTWEAK 可
能参与了血液透析患者冠状动脉钙化的发生、发展。 |
| 英文摘要: |
| Objective:To investigate the association of serum soluble tumor necrosis factor-like weak inducer of apoptosis
(sTWEAK) to coronary artery calcification (CAC) in maintenance hemodialysis (HD) patients.Methods:Sixty HD patients and thirty
healthy volunteers were involved in the study. The levels of sTWEAK were determined by ELISA. Coronary artery calcification score
(CACs) was evaluated by multislice computed tomography scans. The levels of sTWEAK and CACs in two groups were compared.
Spearman analysis was used to assess correlations of sTWEAK levels with CACs and other variables. The stepwise regression analysis
was used to study the predictive factors for CAC.Results:The levels of serum sTWEAK in HD patients were significantly lower than
those in healthy controls [186.23 (148.35, 220.74)pg/mL and 265.13 (210.91, 298.22)pg/mL, respectively P<0.01]. The levels of serum
sTWEAK increased significantly in patients with CACs>400 than those in patients with CACs≤ 400 [220.73(189.70, 251.67)pg/mL and
146.07 (138.43, 180.11)pg/mL, respectively P<0.01]. sTWEAK level showed an positive correlation with CACs (r=0.482, P＜0.01).
Multiple stepwise regression analysis showed that independent risk factors associated with severe CAC were levels of sTWEAK, age,
time on hemodialysis and diabetes (P＜0.05).Conclusion:The levels of serum sTWEAK are decreased in maintenance HD patients.
However, within the HD patients' range, higher sTWEAK was associated with severe CAC. Serum sTWEAK may be involved in the
pathogenesis of CAC in HD patients. |
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