| 徐守竹 吕延英 赵晶 王俊平 年伦
王光建 谢艳华 赵兴 曾艳龙 贾诚 王四旺.肾康注射液对链脲佐菌素诱导的大鼠DN的作用研究[J].现代生物医学进展英文版,2015,15(8):1434-1439. |
| 肾康注射液对链脲佐菌素诱导的大鼠DN的作用研究 |
| The Effects of Shenkang Injection on STZ induced Diabetic NephropathyRat Models |
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| DOI： |
| 中文关键词: 肾康注射液 药效学 糖尿病肾病 血脂 氧化应激 |
| 英文关键词: Shenkang Injection Diabetic nephropathy Blood fat Oxidant stress Pharmacodynamics |
| 基金项目: |
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| 中文摘要: |
| 目的：研究肾康注射液(SKI)对糖尿病肾病(DN)的作用。方法：采用大鼠腹腔注射链脲佐菌素65 mg/kg 体重建立DN 大鼠模
型，SKI高、中、低分别腹腔注射SKI 10 mL/kg，5 mL/kg，2.5 mL/kg ，2 次/天; 正常组和模型组分别给予生理盐水5 mL/kg，2 次/
天；8 周后，观察、测量相应生化和病理等指标。结果：SKI可明显增强DN大鼠肾脏对血肌酐和血尿素氮的清除率，显著降低血液
中总胆固醇、甘油三脂和低密度脂蛋白的含量和升高血液中高密度脂蛋白含量，显著升高血清中T-SOD和CAT 的活力，降低血
清中NO及MDA含量和降低血清中NOS的活力，显著改善糖尿病引起的肾组织损伤。结论：SKI对治疗DN的治疗作用是肯定
的其主要表现在改善血脂代谢紊乱，增强机体抗氧化应激能力及增强肾脏对肌酐和尿素氮的清除能力进而改善肾脏损伤。 |
| 英文摘要: |
| Objective:To investigate the effects of Shenkang Injection (SKI) on diabetic nephropathy (DN).Methods:DN rat
models were established by STZ 65 mg/kg, intraperitoneal injection, and then divided into five groups; SKIH, SKIMand SKIL were give
SKI 10 mL/kg, 5 mL/kg, 2.5 mL/kg, 2 times/d, respectively; While control group and model group were given saline 5 ml/kg, 2 times/d.
After 8 weeks administration, the related biochemical indices were detected.Results:SKI could significantly decrease the level of Scr and
BUN; And it notably decreased the concentrations of T-CHO, TG, LDL and increased the level of HDL in serum; It can increase the
activity of CAT and T-SOD, decrease the concentrations of NO and MDA and inhibit the activity of NOS.Conclusion:SKI can relieve
the damage by high glucose in renal and has obvious therapeutic effect on DN. |
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