| 周峰 方晓东 应广宇 胡未伟 沈宏.一种改良ePTFE人工硬脑膜的实验研究[J].现代生物医学进展英文版,2015,15(8):1406-1408. |
| 一种改良ePTFE人工硬脑膜的实验研究 |
| A Kind of Modified ePTFE Dura Mater: an Experimental Study |
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| DOI： |
| 中文关键词: 膨体聚四氟乙烯（ePTFE） 人工 硬脑膜 |
| 英文关键词: ePTFE Artificial Dura mater |
| 基金项目:浙江省科技厅钱江人才项目（2010R10） |
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| 中文摘要: |
| 目的：对一种ePTFE 人工硬脑膜表面改性，将其外表面疏水特性进行改良，并观察其对兔硬脑膜缺损愈合的影响。方法：对
一种ePTFE 材料人工硬脑膜外表面进行光化学修饰，从而改变其对成纤维细胞吸附能力及促增殖能力。将表面改性后的人工硬
脑膜和未改性人工硬脑膜修补兔硬脑膜缺损，观察其对术后1 周、3 周伤口愈合及脑脊液漏、浸润成纤维细胞、纤维组织厚度等的
影响。结果：未处理组2 只术后早期出现皮下积液，处理组无术后皮下积液的发生（P =0.12）。人工硬脑膜移植术后1 周其外表面
成纤维细胞数目表面改性组要明显多于未处理组（P<0.05）。人工硬脑膜移植术后3 周其外表面纤维组织厚度表面改性组和未处
理组无明显差异（P>0.05）。经过表面改性后的ePTFE 人工硬脑膜其促进组织愈合能力要优于未改性组。结论：对ePTFE材料人工
硬脑膜进行表面改性处理是一种可行有效的改良方法。 |
| 英文摘要: |
| Objective:To observe the influence of a kind of modified ePTFE artificial dura mater on the healing process of rabbit
dura mater defect.Methods:A kind of ePTFE artificial dura mater was modified for its external surface by photo-activated chemical
cross-linking. The surface modified（treatment group）and unmodified (control group) dura mater were transplanted to repair the defected
dura mater in a rabbit model. The wound healing, cerebrospinal fluid leakage, infiltrated fibroblast cells and the thickness of fibrous tissue
were observed in 1 week and 3 weeks after the transplantation.Results:Subcutaneous effusion occurred in 2 rabbits of control group and
none in treatment group in 1 week after transplantation（P =0.12）. The number of fibroblasts in the external surface of artificial dura
mater 1 week after transplantation in the treatment group was significantly greater than control group (P<0.05）. The thickness of fibrous
tissues covering artificial dura mater 3 weeks after transplantation in the treatment group was similar to that in control group (P>0.05）.
The healing process of modified dura mater was better than the unmodified dura mater.Conclusion:The photo-activated chemical
cross-linking for this ePTFE artificial dura mater is effective to improve the quality of artificial dura mater. |
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