李菲菲 唐慧子 吴猛猛 蔡小继 韩 旭.宫颈癌中 SOCS-1 表达的研究新进展[J].现代生物医学进展英文版,2015,15(7):1383-1385. |
宫颈癌中 SOCS-1 表达的研究新进展 |
SOCS-1 Expression in Cervical New Progress in Research |
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DOI: |
中文关键词: 宫颈癌 SOCS-1 甲基化 去甲基化 细胞因 子 HPV E7 |
英文关键词: Cervical cancer SOCS-1 Methylation Demethylation Cytokine HPV E7 |
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中文摘要: |
每年全球大约有 38 万宫颈癌新发病例, 已成为现今世界女性最常见的 妇科恶性肿瘤 之一,高 危型人类乳头瘤病毒
( HPV-16、18 等)是公认的宫颈癌的致病因 素。 研究证实 HPV E7 原癌基因的产物 HPV E7 原癌蛋白通过与 抑癌蛋白 pRb 结合, 诱
导 pRb 的降解,导致宫颈上皮细胞永化生, 致细胞生长增殖失控及细胞凋亡程序发生异常是 HPV 诱导宫颈癌发生的一个主要机
制 。 细胞因 子信号传导抑制蛋白 ( suppressor of cytokine signaling, SOCS)家族是由细胞产生的,可通过反馈调节来阻断细胞因 子信
号转导过程的一类负 性调节因 子, SOCS-1 可抑制多 种细胞因 子的信号转导途径, 调控体内 多 种免疫反应,现有研究表明 SOCS-1
可通过诱导 E7 蛋白降解来抑制 HPV E7 介导的异常转化。 而且 socs-1 在癌细胞中表达明显降低, 说明 SOCS-1 可能是抑癌基因 ,
其失活机制主要是甲基化和杂合性缺失, 所以说 SOCS-1 的甲基化和杂合性缺失对宫颈癌的发生、发展起着至关重要的作用 ,因
此 SOCS-1 的去甲基化及打破基因 沉默可能是一种潜在的治疗宫颈癌的新策略。 |
英文摘要: |
There are about 380000 new cases of cervical cancer every year, which has become one of the most common female
gynecologic malignant tumor in the world today, and the high-risk human papillomavirus (HPV-16, 1 8) is acknowledged as a causal factor in cervical carcinoma. The study confirmed that HPV proto-oncogene E7 produced HPV E7 oncogene binds to the tumor suppressor
protein pRb, and degrades ipRb, resulting in cervical epithelial cells metaplasia. The important mechanism of cervical carcinoma is to induce cell proliferation out of control and apoptosis induced by HPV exception. The SOCS family is produced by the cell, and blocks a
negative cytokine signal transduction regulators through the feedback regulation. SOCS-1 can inhibit signal transduction pathway of a variety of cytokines, and regulate a variety of immune responses. The current study shows that E7 protein degradation induced by SOCS-1
inhibit the abnormal transformation of the HPV mediated by E7. And SOCS-1 in cancer cells was significantly decreased, indicating that
SOCS-1 may be a tumor suppressor gene, whose main mechanism is its inactivation methylation and loss of heterozygosity, so SOCS-1
methylation and loss of heterozygosity plays a vital role on the cervical cancer occurrence, Therefore, the SOCS-1 demethylation and
break gene silencing may be a new strategy for the potential treatment of cervical cancer. |
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