| 金 亮 孙 闯 于大淼 徐 英 郑未来 廉永云.中药防治假体周围骨溶解的研究进展[J].现代生物医学进展英文版,2015,15(7):1380-1382. |
| 中药防治假体周围骨溶解的研究进展 |
| Research Progress of Chinese Medicine to Prevent Periprosthetic Osteolysis |
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| DOI： |
| 中文关键词: 中药 OPG RANKL 成骨细胞 破骨细胞 |
| 英文关键词: Traditional Chinese medicine OPG RANKL Osteoblasts Osteoclasts |
| 基金项目:黑龙江省教育厅科学技术研究项目（ GC09C412-3） |
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| 中文摘要: |
| 现如今人工关节置换术越来越多 的应用 于重建关节功能改善关节疾病患者的生活质量， 但是术后并发症严重影响了 手术
的效果， 人工假体周围 骨溶解及假体无菌性松动又是人工关节置换术后失败的主要原因 之一， 所以如何预防以及发病后如何去
治疗成为现今关节医生面临的重要课题。 OPG/RANKL/RANK 系统， 炎性因 子的产生， 破骨细胞、成骨细胞这些都是影响人工假
体术后产生无菌性松动， 和引 发假体周 围 骨溶解的重要因 素， 有效药物的干预治疗成为现如今关节置换术后以及围手术期的热
门 话题，中药因 其副作用小， 疗效独特，及深入的研究逐渐受到 广大医生的注意，因 此中药在治疗人工假体松动及骨溶解方面也
得到了 重大突破，本文从中医肾藏精， 精生髓，髓能养骨理论着手总结中药作用 于 OPG/RANKL/RANK 系统， 抑制炎性因 子、破骨
细胞及促进成骨细胞增殖的研究现状。 |
| 英文摘要: |
| Now arthroplasty more and more used in the reconstruction of joint function to improve the quality of life in patients
with joint disease, but serious postoperative complications affecting the effect of the surgery, artificial periprosthetic osteolysis and aseptic
loosening one of the main reasons for artificial joint replacement surgery failed, so how to prevent and how to go after the onset of treatment has become an important issue that the joint doctors face. OPG/RANKL/RANK system, inflammatory cytokine production, osteoclasts, and osteoblasts are affecting the prosthesis postoperative produce aseptic loosening, and raises an important factor in periprosthetic
osteolysis, effective drug intervention treatment has become a hot topic now in joint replacement surgery and perioperative medicine because of its side effects, unique effect, and in-depth research gradually by the attention of the majority of doctors, Chinese medicine in the
treatment of prosthesis loosening and osteolysis has also been a major breakthrough. From the Chinese kidney storing the essence, the
essence bringing forth marrow, and the theory that marrow can raise bone, this review summarizes the research status of the traditional
Chinese medicine acting on the OPG/RANKL/RANK system, inhibition of inflammatory factors, osteoclasts and promote bone cell proliferation research. |
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