| 王 博 曹引丽 邱洪涛 贾卉 刘嗣超.孕早中期血清脂联素、抵抗素、铁蛋白水平及与妊娠期糖尿病的相关性分析[J].现代生物医学进展英文版,2015,15(7):1321-1323. |
| 孕早中期血清脂联素、抵抗素、铁蛋白水平及与妊娠期糖尿病的相关性分析 |
| Correlative Analysis of the Serum Levels of Adiponectin, Resistin andFerritin in Early and Median Pregnancy with Gestational Diabetes Mellitus |
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| DOI： |
| 中文关键词: 脂联素 抵抗素 血清铁蛋白 妊娠期糖尿病 相关性分析 |
| 英文关键词: Adiponectin Resistin Serum ferririn(SF) Gestational diabetes mellitus(GDM) Correlative analysis |
| 基金项目:陕西省卫生厅科研基金项目（ 2010H12） |
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| 中文摘要: |
| 目的： 研究孕早中期血清抵抗素、脂联素及铁蛋白水平与 妊娠期糖尿病的相关性。 方法： 选取孕早期(1 1-13 周 )、孕中期 (24-28
周 )诊断为 GDM 的孕妇 46 例 作为试验组(GDM 组)，及同期糖代谢正常的孕妇 46 例作为对照组(NGT 组)， 检测和比较两组孕早、
中期血清脂联素、抵抗素、铁蛋白 水平， 计算各期胰岛素稳态模型抵抗指数(HOMA-IR)， 并对孕早中期血清抵抗素、脂联素及铁蛋
白 (SF)水平与 HOMA-IR 进行相关性分析。 结果： 与 NGT 组比较， GDM 组孕早、中期血清脂联素水平均显著降低，且孕早期血清
脂联素水平与 HOMR-IR 呈负 相关(r=-0.21， P<0.05)； 孕早、中期血清 SF 水平均显著升高，且孕早期血清 SF 水平与 IR 呈正相关
(r=0.238， P<0.05)；孕早期血清抵抗素水平无明显变化(P>0.05)， 但孕中期血清抵抗素水平显著降低(P<0.05)。 多 元线性回归分析结
果显示孕早期血清铁蛋白 水平对 HOMA-IR 的影响更显著， 孕早期 SF 每升高 1 滋g/l， HOMA-IR 提高 0.1 79。 孕早期 SF 水平作为
预测 GDM 发病的血清学阈值为 ≥ 23.2 滋g/L。 结论： 孕早期血清脂联素及 SF 水平变化均与 GDM 的发病相关， 孕早期血清 SF 水
平可能作为早期诊断和预防 GDM 的血清学指标。 |
| 英文摘要: |
| Objective:To study the relationship between serum levels of adiponectin, resistin, and ferritin in the early and middle
stage of pregnancy and insulin resistance of GDM.Methods:The serum levels of adiponectin, resistin and ferritin were obtained from the
patients with GDM (n=46) and nomal glycometabolism(NGT n=46) in the early(11 -13weeks) and median(24-28weeks) stage ofpregnancy,
The correlation of serum levels of adiponectin, resistin and ferritin with HOMA-IR were analyzed.Results:Compared with the NGT
group, the serum levels of adiponectin in the early and middle stage of pregnancy were significantly lower, the serum levels of
adiponectin in the early stage of pregnancy had negative relationship with the HOMA-IR(r=-0.21, P<0.05). The serum levels of ferritin in
the early and middle stage of pregnancy were obviously higher, and the serum level of ferritin in early stage of pregnancy was positively
correlated with the HOMA-IR (r=0.238, P<0.05). No significant difference was found in the serum level of resistin in early stage of pregnancy (P>0.05), but the serum level of resistin in middle stage of pregnancy was significantly higher (P<0.05). Multiple linear regression
analysis showed the serum level ferritin in early stage of pregnancy influenced the HOMA-IR more obviously, with the increase of serum
level of ferritin in early stage of pregnancy by 1 滋g/l, HOMA-IR enhanced by 0.1 79. The threshold of serum level of ferritin in early stage
of pregnancy was ≥ 23.2 ug/L in the prediction of GDM.Conclusion:The changes of serum levels of adiponectin, ferritin in early stage
of pregnancy were both related to the incidence of GDM, the serum level of SF in early stage of pregnancy may be used as the serum
marker for the early diagnosis and prevention of GDM. |
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