| 朱丽秀 林新雁 聂成军 陈仁利.唇腺活检、自身抗体在干燥综合征诊断中的意义[J].现代生物医学进展英文版,2015,15(7):1307-1309. |
| 唇腺活检、自身抗体在干燥综合征诊断中的意义 |
| The Role of Lip Histopathology and Autoantibody in the Diagnostic forSj觟gren's Syndrome |
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| DOI： |
| 中文关键词: 干燥综合征 唇腺病理 自 身抗体 诊断 |
| 英文关键词: Sj觟gren's syndrome Lip histopathology Autoantibody Diagnosis |
| 基金项目: |
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| 中文摘要: |
| 目 的： 探讨干燥综合征(ss)患者的唇腺活检病理表现、自 身抗体及其在诊断中的意义。 方法： 收集 85 例干燥综合征患者的临
床体征、唇腺活检以及其他相关辅助检查， 对其唇腺活检病理标本及相关检查进行分析。 结果： 根据唇腺病理结果， 单纯唇腺活检
的阳性率为 68.2%； 单纯血清抗 SSA/SSB 抗体检出 阳性率为 78.8%； 联合唇腺活检、抗 SSA/SSB 抗体疾病检出 率达 94.1%，与 单
纯唇腺活检或抗 SSA/SSB 抗体单项阳性的疾病检出率有统计学意义（ P<0.05）； 并且唇腺活检阳性患者较阴 性患者口 干或眼干持
续时间长（ P<0.05）； 但腮腺 ECT 异常、关节肿痛、肺脏损害均较唇腺活检阴 性组患者累 及率高， 但差异无统计学意义（ P>0.05）。 结
论： 唇腺活检、自 身抗体是诊断干燥综合征的必要检查，而其联合应用 更具有举足轻重的意义。 |
| 英文摘要: |
| Objective:To explore their significance of lip histopathology and autoantibodies in diagnosis of Sj 觟gren's syndrome
(ss).Methods:We collected clinical signs,lip biopsies and other auxiliary examination of 85 patients with Sj觟gren syndrome, lip biopsies
and related inspections were analyzed.Results:According to the pathological changes of lip biopsy, the positive rate was 68.2% in 85 patients. Single serum anti SSA/SSB antibody positive rate was 78.8%. Combined serum anti SSA/SSB antibody positive with lip histopathology can diagnose 94.1 % patients of SS. It was statistically significant compared with simple labial gland biopsy or SSA/SSB single positive (P<0.05). And labial gland biopsy positive patients had longer duration than negative patients with dry mouth or dry eyes (P<0.05).
Those with pathological positive had slightly higher incidence of the parotid ECT, joint pain, and lung damage than the negative patients
(P>0.05).Conclusion:Lip histopathology and autoantibodies are necessary to the diagnosis of ss, but the combined application has important significance. |
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