| 沈明强 刘鑫 魏晨 席丽艳 惠觅宙.生物活性透明质酸治疗激光所致皮肤创口 炎症的临床疗效观察[J].现代生物医学进展英文版,2015,15(7):1300-1303. |
| 生物活性透明质酸治疗激光所致皮肤创口 炎症的临床疗效观察 |
| Observation on the Clinical Efficacy of Bioactive Hyaluronic Acid Fragment in the Treatment of Laser Induced Skin Wound |
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| DOI： |
| 中文关键词: 生物活性透明质酸 内 毒素拮抗剂 皮肤创口 炎症 |
| 英文关键词: Bioactive hyaluronic acid TLR4 LPS antagonist Skin wound Inflammation |
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| 中文摘要: |
| 目的： 探讨生物活性透明质酸治疗激光所致皮肤创口炎症的临床疗效。 方法： 选择我院收治的 40 例激光皮肤除斑患者为研
究对象， 按就诊顺序将其分为实验组和对照组。 实验组 20 例患者采用 生物活性透明质酸涂抹激光治疗后的皮肤伤口 ， 对照组 20
例患者采用 30 分冰袋冷敷皮肤激光治疗后的皮肤伤口， 观察和比较两组患者伤口 第 1 -7 天的的红肿痛的改善情况。 结果： (1)疼
痛 症状的改善情况： 实验组第 1 天的显效率 0%， 有效 20 例， 总有效率 100%； 对照组第 1 天的显效率 0%， 有效 20 例， 总有效率
100%
， 两组比较无统计学差异(P>0.05)。 (2)红肿的改善情况： 实验组第 1 天显效 20 例， 总有效率为 100%； 对照组第 1 天显效 0
例， 有效 20， 总有效率为 100%， 两组总有效率比较无统计学差异(P>0.05)，但实验组的显效率明高于对照组， 差异具有统计学意义
(P<0.01)。 结论： 生物活性透明质酸涂抹可以有效控制皮肤伤口 炎症引 发的红肿痛 ，且临床效果明显优于冰袋冷敷，方便可行， 值
得推广。 |
| 英文摘要: |
| Objective:The aim of this study was to investigate clinical effect of topical application of bioactive hyaluronic acid
fragment to regulate skin wound induced inflammatory reaction.Methods:Total 40 patients were divided into two groups. Experimental
group and control group, each with 20 patients. Bioactive hyaluronic acid fragment was topically used to treat laser treatment induced
acute facial skin wound in order to control inflammatory reaction and healing in the experimental group. Then, wound inflammatory reaction including pain, redness, and swelling was monitored. Cold compress of 30 minutes was used in the control group.Results:(1) Inflammatory pain: Both 20 patients in experimental group and control group all feel mild pain after the treatment of cold compress(P>0.05). (2)
Clinical sign: wound redness and swelling in 20 patients of experimental group were inhibited significantly better than that of control
group (P<0.01).Conclusion:Topical application of bioactive hyaluronic acid fragment significantly inhibits skin wound inflammatory reaction and does not affect healing process, suggesting its clinical role to replace cold compress and positively regulate wound inflammation and healing. |
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