| 张高高 郑国宝 王仰坤 原旭涛 贠田 蒙念龙 吕学霞.大肠癌组织中 TS 和 COX-2 的表达及其与患者无病生存期的关系[J].现代生物医学进展英文版,2015,15(7):1297-1299. |
| 大肠癌组织中 TS 和 COX-2 的表达及其与患者无病生存期的关系 |
| Relationship between the DFS and Expression of TS, COX-2 in ColorectalCancer |
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| DOI： |
| 中文关键词: 环氧化酶 -2 胸苷酸合成酶 无病生存期 大肠癌 |
| 英文关键词: Cyclooxygenase-2 (cox-2) Thymidylate Synthase (TS) Disease-free survival (DFS) Colon cancer |
| 基金项目:全军医药卫生科研基金项目（ 08Z006） |
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| 中文摘要: |
| 目的： 探讨大肠癌患者癌组织中环氧化酶 -2(COX-2)、胸苷酸合成酶(TS)的表达及其与患者无病生存期的关系。方法： 筛选我
院收治的大肠癌根治术患者，选择无病生存期大于 48 个月 者 30 例和无病生存期小于 48 个月 者 29 例。 采用 免疫组化法检测大
肠癌组织中 COX-2 和 TS 的表达， 并分析其与 患者无病生存期的关系。 结果： 49 例结直肠癌患者中， TS 的阳性表达率为 91.84%，
COX-2 的阳性表达率为 77.55%。不同 无病生存期的大肠癌患者 TS 的表达水平比较无统计学差异(P=0.646)。 COX-2 在无病生存
期 >48 个月 的患者癌组织中表达水平明显低于无病生存期 <48 个月 的患者， 差异有统计学意义(P=0.033)。 结论： COX-2 与 大肠癌
患者的无病生存期显著相关，可能成为预测大肠癌预后的参考指标。 |
| 英文摘要: |
| Objective:To investigate the correlation of cyclooxygenase-2 (COX-2) and thymidylate synthase (TS) expressions in
Cancerous tissue with the disease free survival of patients with colorectal cancer.Methods:30 patients with colorectal cancer whose disease-free survival were more than 48 months and 29 patients with colorectal cancer whose disease-free survival were less than 48 months
were selected and underwent radical surgery in our hospital. The expression of COX-2 and TS in Cancerous tissue were detected by immunohistochemistry, the relationship between them and disease-free survival were analyzed.Results:In 49 patients with colorectal cancer, the positive expreesion rate of TS and COX-2 were 91.84% and 77.55%, respectivly. No significant difference was found in the expression of TS between the patients with different disease-free survival (P=0.646). The expression of COX-2 of patients whose DFS were
longer than 48 months were significantly lower than those whose DFS were shorter than 48 months (P=0.033).Conclusion:COX-2 was
significantly related to the disease-free survival of patients with colorectal cancer, which might be a marker to predict the prognosis of
colorectal cancer. |
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