| 张国 秀 赵 鑫 沈 陵 王俊红 李 洁.盐酸戊乙奎醚治疗有机磷中毒重度中间综合症临床研究[J].现代生物医学进展英文版,2015,15(7):1294-1296. |
| 盐酸戊乙奎醚治疗有机磷中毒重度中间综合症临床研究 |
| Clinical Study of Penehyclidine Hydrochloride in the Treatment of SevereOrganic PhosPhorus Poisoning Intermediate Syndrome |
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| DOI： |
| 中文关键词: 急性有机磷中毒 盐酸戊乙奎醚 中间综合症 |
| 英文关键词: Acute organic PhosPhorus Poisoning Penehyclidine hydrochloride Intermediate syndrome |
| 基金项目:河南卫生厅科技攻关项目 (20090311 1) |
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| 中文摘要: |
| 目 的： 探讨分析盐酸戊乙奎醚在急性有机磷中毒重度中间综合症治疗中的效果。 方法： 选取急性有机磷中毒并发重度中间
综合症患者 34 例， 依治疗 方案分为对照组和观察组， 各 17 例。 2 组患者基础治疗 相同 ，对照组给予氯解磷定 + 阿托品 + 机械通气
治疗；观察组采用 氯解磷定 + 盐酸戊乙奎醚 + 机械通气治疗。 观察比较 2 组患者肌无力症状消失时间、机械通气时间以及住院时
间 。 结果： 观察组患者 肌无力 症状消失时间、机械通气时间 以及住院时间均明 显低于对照组， 经比较， 差异均有统计学意义( P＜
0.01)。 结论： 盐酸戊乙奎醚可快速有效缓解急性有机磷中毒重度中间 综合症患者的临床症状，显著缩短病程。 |
| 英文摘要: |
| Objective:By analyzing the acute severe organic PhosPhorus Poisoning Intermediate syndrome to acquaintance the
treatment about the efficacy of Penehyclidine hydrochloride.Methods:34 cases of acute organic PhosPhorus Poisoning Intermediate syndrome were selected and divided into the control group and the therapeutic group. Each group had 1 7 cases and based on the same treatment. Patients in the control group were treated with Pralidoxime Chloride + Atropine + Mechanical ventilation, and in the therapeutic
group were treated with Pralidoxime Chloride + Penehyclidine Hydrochloride + Mechanical ventilation. The length of myasthenia lasting,
mechanical ventilation using and the hospital stay were observed and compared.Results:The length of myasthenia lasting, mechanical
ventilation using and the hospital stay in the therapeutic group was much shorter than the observations in control group (P<0.01).Conclusion:Penehyclidine Hydrochloride can effectively alleviate the symptom of acute severe organic Phosphorus Poisoning Intermediate syndrome
fast and shorten the course of disease greatly. |
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