| 吴琳 唐敏英 张美娜 姜孝新.乙肝免疫标志物与乙肝病毒核酸含量与肝功能的关系研究[J].现代生物医学进展英文版,2015,15(7):1241-1244. |
| 乙肝免疫标志物与乙肝病毒核酸含量与肝功能的关系研究 |
| Relationship of Hepatitis B Immune Markers and HBV-DNA Contentwith Liver Function |
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| DOI： |
| 中文关键词: 乙肝 乙肝病毒脱氧核苷酸 免疫标记物 肝功能 |
| 英文关键词: Hepatitis B Hepatitis B virus deoxynucleotides Immune markers Liver function |
| 基金项目:卫生部医药卫生科技发展研究中心项目（ W2013GJ09）； 湖南省自然基金项目（ 14JJ2092） |
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| 中文摘要: |
| 目的： 研究乙肝免疫标记物（ HBV-M）与 乙肝病毒脱氧核苷酸（ HBV-DNA）载量与 肝功能的关系。 方法： 检测 104 例乙肝患者
HBsAg、 HBeAg、 HBcAb、HBsAb、 HBeAb5 种 HBV-M； 用 PCR 法检测 HBV-DNA 含量；同 时检测天冬氨酸氨基转移酶 (AST)、丙
氨酸氨基转移酶(ALT) 、胆碱酯酶(CHE) 等肝功能指标，对三者关系采用 Spearman 相关性分析。 结果： HBsAg、 HBcAb、 HBeAg 阳
性组 HBV-DNA 阳性率及载量均大于其余组（ P<0.05）； HBeAg 含量、 ALT 浓度与 HBV-DNA 载量均呈正相关（ r = 0.48, P<0.05)、
（ r=0.36, P<0.05）； AST、CHE 与 HBV-DNA 含量无明显相关性， 但在无病毒载量与 有病毒载量组之间 AST 比较有统计学意义
（ P<0.05)。 结论： HBV-M、 HBV-DNA 与 肝功能之间 有一定的相关性， 但 HBeAg 阴转不代表病毒复制停止， HBV-DNA 也不能完全
反应肝损害程度， 临床应加大重视。 |
| 英文摘要: |
| Objective:To study the relationship of HBV-M and HBV-DNA content with liver function.Methods:Detected the
HBsAg, HBeAg, HBcAb, HBsAb and HBeAb levels of 104 hepatitis B patients. PCR method was used to detect their HBV-DNA levels.
Meanwhile, their aspartate aminotransferase(AST), alanine aminotransferase enzymes(ALT), cholinesterase(CHE) levels were detected,
and their relations between each other were obtained by using Spearman correlation analysis.Results:The positive rate of HBV-DNA
and its load volume was greater in HBsAg, HBcAb, HBeAg-positive group than in the other groups(P<0.05). The HBeAg levels and ALT
concentration was positively correlated with HBV-DNA load (r=0.48, P<0.05), (r=0.36, P<0.05). AST and CHE showed no significant
correlation with HBV-DNA load, but AST between no viral group and viral group showed statistical difference (P<0.05)Conclusion:There is a certain correlation between HBV-M, HBV-DNA and liver function. But HBeAg seroconversion does not mean to stop viral
replication, and yet HBV-DNA can not completely reflect liver damage. So we should pay more attention in clinic. |
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