| 张璇 张卓然 段淑荣 蒋莱 范志新.跑台训练与强制性运动对脑梗死大鼠神经功能恢复的对比性研究[J].现代生物医学进展英文版,2015,15(7):1226-1229. |
| 跑台训练与强制性运动对脑梗死大鼠神经功能恢复的对比性研究 |
| Comparative Study of Treadmill Training and Constraint-induced MovementTherapy on the Recovery of Neural Function in Rats with CerebralInfarction |
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| DOI： |
| 中文关键词: 强制性运动 跑台训练 康复训练 脑梗死 神经功能缺损 |
| 英文关键词: Constraint-induced movement therapy Treadmill training Rehabilitation training Cerebral infarction Nerve function defect |
| 基金项目:黑龙江省青年科学基金项目 (QC201 3C1 04) |
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| 中文摘要: |
| 目的： 探讨跑台 训练与 强制性运动康复训练对脑梗死大鼠神经功能恢复的差异。 方法： 将 50 只 SD 雄性大鼠随机分为正常
组、假手术组、模型组、跑台训练组（ T 组）、强制性运动训练组（ C 组）， 每组 10 只， T 组及 C 组于造模后 24 h 分别 进行跑台训练及
强制性运动训练， 其他各组正常饲养。 于术后 14 天、 21 天及 28 天分别进行神经功能缺损评分（ NSS 评分）， 随后取脑采用 免疫组
织化学方法观察脑梗死灶周 围巢蛋白（ Nestin）、半胱氨酸天冬氨酸蛋白 酶 -3（ Caspase-3）、神经胶质酸性蛋白（ GFAP）的表达。 结
果： 各亚组同 一时间 NSS 评分组间比较： C 组、 T 组评分高于正常组及假手术组， 但明显低于模型组(P<0.05)； C 组评分明 显低于 T
组 (P<0.05)；各组内 比较差异无统计学意义(P>0.05) 。 C 组、 T 组 Caspase-3 的表达明显低于正常组、假手术组及模型组(P<0.05)，而
Nestin、GFAP 的表达高于正常组、假手术组及模型组(P<0.05)。 T 组 Caspase-3 的表达明显高于 C 组(P<0.05)， Nestin、GFAP 的表达
低于 C 组(P<0.05)。 结论： 跑台训练与 强制性运动康复训练 2 种方法对脑梗死大鼠神经功能恢复均有效； 强制 性运动的效果优于
跑台训练。 |
| 英文摘要: |
| Objective:To investigate the difference between treadmill training and constraint-induced movement therapy on the
neural function after middle cerebral artery occlusion in rats.Methods:50 healthy female SD rats were randomly divided into 5 groups:
normal group, sham operation group, model group, treadmill training group (T group) and constraint-induced movement therapy group(C
group), with 1 0 rats in each group. Treadmill training and constraint-induced movement therapy were used respectively for T group and C
group after modeling, while rats in the other groups were given normal feeding. The neurologic impairment scores(NSS) were analyzed at
14 days, 21 days and 28 days respectively after operation. And immuno-histochemical technique was used to observe the expression levels of Nestin, Caspase-3 and GFAP in cortical ischaemic lesions of the rats in each group after 28 days.Results:Comparison of each sub
group at the same time: the scores of NSS in C group and T group were significantly higher than that in normal group and sham operation
group, but lower than that in the model group (P<0.05); the scores of NSS in C group were significantly lower than that in the T group
(P<0.05). There was no significant difference at the different time points in the same group (P>0.05). The expression levels of Caspase-3
in C group and T group were significantly lower than that in normal group, sham operation group and model group(P<0.05), while the expression levels of Nestin and GFAP were just the opposite(P<0.05); the expression levels of Caspase-3 in T group significantly were lower than that in C group (P<0.05), but the expression levels of Nestin and GFAP were just the opposite (P<0.05).Conclusion:The two
methods of treadmill training and constraint-induced movement therapy were effective on neural functional recovery in rats with cerebral
infarction; constraint-induced movement therapy was better than treadmill training. |
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