| 崔清昱 1 孙传东 1△ 张炳远 1 刘 世海.MiRNA-221/222 对肝癌的影响研究进展[J].现代生物医学进展英文版,2015,15(6):1174-1177. |
| MiRNA-221/222 对肝癌的影响研究进展 |
| MiRNA-221 /222 Involvement in Hepatocarcinoma |
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| DOI： |
| 中文关键词: 肝癌 miRNAs miR-221/222 |
| 英文关键词: HCC miRNAs miR-221/222 |
| 基金项目:山东省 2012 科学技术发展计划（ 2012G0021 845）； 山东省自然科学基金项目（ 201 1ZRB01588） |
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| 中文摘要: |
| MicroRNAs（ miRNAs）在人类肿瘤致瘤生长机制的作用 在肝细胞肝癌（ hepatocellular carcinoma, HCC）中已经通过基因增殖
和功能性研究所证实。 肝癌中 异常表达的 miRNAs 与其他类型的 肿瘤有密切关系， 其中较为 独特的 是上调的 miR-221 /222。
MiR-221 /222 是高度同 源基因 ，在 HCC 中明 显上调， 被认为是致瘤基因。 本文对 miR-221 /222 的分子及生物机制进行综述， 并对
其作为新的 HCC 诊断及治疗工具的可能性做出探讨。 |
| 英文摘要: |
| The role of mircroRNAs (miRNAs) in human tumorigenesis has been demonstrated by gene profiling and functional
studies in hepatocellular carcinoma (HCC). Their aberrant expression revealed relations shared with other types of cancer ,namely the
up-regulation of miR-221/222. MiR-221/222 are two highly homologous microRNAs, whose upregulation has been obviously showed in
HCC, which also has been considered to act as oncogenes. Here we will review the role of miR-221 /222 in molecule and biomechanism,
and explore the possibility of their use as new prognostic and therapeutic tools in HCC. |
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