| 赵姝妤 吕 楠 褚晓丹 王 林 陈 萱△.PI3K 与乙型肝炎病毒宫内感染的相关研究[J].现代生物医学进展英文版,2015,15(6):1145-1147. |
| PI3K 与乙型肝炎病毒宫内感染的相关研究 |
| PI3K Intrauterine Infection with Hepatitis B Virus |
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| DOI： |
| 中文关键词: 乙型肝炎病毒 HBxAg 宫内 感染 信号通路 |
| 英文关键词: HBxAg Intrauterine infection Signaling pathway |
| 基金项目:黑龙江省教育厅海外学人项目（ 1153h14） |
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| 中文摘要: |
| 慢性乙型肝炎病毒(Hepatitis B virus， HBV)感染是全世界关注的公共卫生问题。 我国是乙肝高流行区， 每年约有 150 万乙肝
病毒携带者分娩，近半数胎儿通过母婴垂直传播感染乙肝。 由于婴幼儿期感染乙肝后形成的免疫耐受，往往成为慢性甚至终身携
带者，逐渐发展为肝硬化、肝癌。 近年来的研究发现， PI3-Akt 信号通路与 妊娠生及或病理过程关系密切，在感染 HBV 的胎盘组织
中发现 PI3K-Akt 信号通路中相关蛋白表达异常增高， 且 HBxAg 干扰该通路调节凋亡功能。推断 HBxAg 通过调节 PI3K-Akt 信号
通路活性影响胎盘功能，是 HBV 宫内 感染的一种重要分子机制。 为今后阻断 HBV 宫内 感染提供新的研究方向。 |
| 英文摘要: |
| Chronic hepatitis B virus (Hepatitis B virus, HBV) infection is a public health problem of worldwide concern. Of high
hepatitis B prevalence area, each year about 1.5 million hepatitis B virus carriers childbirth, about 80 million children may be infected
through vertical transmission. Infant immune tolerance phase of infection, the infection often become chronic and even lifelong carriers,
and the development of cirrhosis, liver cancer. Recent studies have found that the PI3-Akt signaling pathway pregnancy Health and
pathological processes of close relationship, the study found abnormally high levels of PI3K-Akt signaling pathway protein found in the
placental tissue infected with HBV, and interfere with the pathway HBxAg withered The perish function. To infer HBxAg affect
placental function by regulating the activity of PI3K-Akt signaling pathway, an important molecular mechanism of HBV intrauterine
infection. Provide a new direction for future blocking HBV intrauterine infection. |
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