| 宁宛亭 1 孙夕 林 1，2 王 凯 1，2 王 丹 1，2 申宝忠.磁共振技术在轻度认知障碍与阿尔茨海默病中的研究进展[J].现代生物医学进展英文版,2015,15(6):1141-1144. |
| 磁共振技术在轻度认知障碍与阿尔茨海默病中的研究进展 |
| The Progress of Researching on Mild Cognitive Impairment and Alzheimer'sDisease by MRI Techniques |
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| DOI： |
| 中文关键词: 阿尔茨海默病 轻度认知障碍 磁共振成像 |
| 英文关键词: Alzheimer's disease Mild cognitive impairment MRI |
| 基金项目:国家自然科学基金重点项目（ 81 130028）；国家自然科学基金重大国际（地区）合作项目（ 312101 03913）；
黑龙江省科技攻关重大项目（ GA1 2C302） |
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| 中文摘要: |
| 阿尔茨海默病（ Alzheimer's disease, AD）是当 今老年人最常见的一种原发性神经退行性疾病。 其主要病理学特征表现为 神
经元的脱失、神经纤维缠结及老年斑形成。 轻度认知障碍（ mild cognitive impairment, MCI）被认为是 AD 及其他老年痴呆症的前驱
阶段，可进一步转化成 AD， 且 MCI 与 AD 有着相似的病理变化。 随着 MCI 和 AD 患病数的逐年增加， 其给患者家属及社会增添
了 巨大负担，因 此，对 MCI 和 AD 作出早期诊断变得尤为重要。 然而， MCI 和 AD 早期的临床表现并不突出， 且实验室检查也缺乏
足够的特异性，当 临床医生做出 明确诊断时， 多 数患者已处于 AD 的中晚期。 近年来，随着磁共振技术的不断发展， 多 种磁共振技
术已广泛地应用 于 MCI 和 AD 的研究中， 并为 MCI 及 AD 的早期诊断提供了 重要的影像学依据。 本文分别从结构性磁共振
（ sMRI）、静息态 fMRI、磁共振弥散张量成像（ DTI）、磁共振波谱成像（ MRS）、磁敏感加权成像（ SWI）及 MRI 分子影像几个方面，
阐 述多 种磁共振技术在 MCI 和 AD 研究中的进展。 |
| 英文摘要: |
| Alzheimer's disease (AD) is one of the most common neurodegenerative diseases in elder adult. Its main pathology is
characterized by loss of neurons, neurofibrillary tangles and senile plaques. Mild cognitive impairment (MCI) often lead to AD and it is
considered as the early-stage of AD as there are so many similar pathological changes between them. With the increasing of the AD and
MCI, it places tremendous burden on the patients , their families and the community. So an early diagnosis is hugely important, while
there is no specific method neither in clinic nor basic research can achieve that. When the clinician made a clear diagnosis, most patients
had been in the middle or late stage of AD. In recent years, multiple technologies of magnetic resonance imaging are playing an important
role in the early detection of MCI and AD, and they are considered to accomplish this goal. In this paper, we are going to expound
multiple magnetic resonance technologies in the MCI and AD research progress.from structural magnetic resonance imaging (sMRI),
functional magnetic resonance imaging (fMRI), magnetic resonance diffusion tensor imaging (DTI), magnetic resonance spectroscopy
(MRS), magnetic susceptibility weighted imaging (SWI) and MRI molecular imaging aspects. |
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