吴 炜 张超峰 陆 萍 费哲为.SDF-1 在乳腺癌患者血清中表达水平及临床意义[J].现代生物医学进展英文版,2015,15(6):1080-1083. |
SDF-1 在乳腺癌患者血清中表达水平及临床意义 |
Serum Levels of SDF-1 in Breast Cancer and its Clinical Significance |
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DOI: |
中文关键词: 乳腺癌 Elisa SDF-1 远处转移 |
英文关键词: Breast Cancer Elisa SDF-1 Distant metastasis |
基金项目:崇明县科委科研基金( CKY201 0-10) |
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中文摘要: |
目的: 分析 SDF-1 在乳腺癌患者外周血中的表达水平,探讨其临床意义。 方法: Elisa 法检测乳腺癌患者术前及术后血清
SDF-1 水平, 分析其与 乳腺癌临床病理特征的关系。 结果: 乳腺癌患者术前( 69 例)血清 SDF-1 水平明显高于正常对照组( 20 例)
( 6406.7± 1 302.5 pg/mL vs 521 7.4± 1225.7 pg/mL), 有明 显统计学差异( P<0.01),发生远处转移的乳腺癌患者( 11 例)血清 SDF-1
水平明 显高于未发生转移者( 58 例)( 7656.4± 784.1 pg/mL vs 6169.7± 1 364.6 pg/mL), 差异具有明显统计学意义(P<0.01)。 ER 及
Her-2 表达阳性乳腺癌的患者 SDF-1 水平较 ER 及 Her-2 表达阴 性者低, 差异亦有统计学意义( P<0.05)。 结论: SDF-1 可能是预测
乳腺癌发生及远处转移的重要标志物。 |
英文摘要: |
Objective:This study was conducted to investigate the value of the pretreatment circulating stromal cell derived
factor-1 (SDF-1) in patients with breast carcinoma.Methods:We measured SDF-1 serum concentrations and evaluated the relationship
between serum SDF-1 and clinical factors in preoperative and postoperative breast cancer patients.Results:Serum levels of SDF-1 is
higher in breast cancer patients than in controls (P <0.01), Serum levels of SDF-1 is higher in metastatic patients than non-metastatic
patients (P <0.01 ). Serum levels of SDF-1 is higher in ER and Her-2 positive breast cancer patients than ER and Her-2 negative patients
(P <0.05).Conclusion:SDF-1 might serve as a possible marker predicting development or distant metastasis in breast cancer. |
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