| 孙 盈 王雪娇 夏靖华 文苗苗 邢 昊 庞赛楠 李小飞 △ 张志培△.Fn14 在 EGFR 外显子 19 缺失突变的非小细胞肺癌中的表达及其临床意义[J].现代生物医学进展英文版,2015,15(6):1064-1068. |
| Fn14 在 EGFR 外显子 19 缺失突变的非小细胞肺癌中的表达及其临床意义 |
| Expression and Clinical Significances of Factor-inducible 1 4 in NSCLC withDeletion of EGFR exon 19 |
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| DOI： |
| 中文关键词: 成纤维细胞生长因子诱导 14 非小细胞肺癌 表皮生长因子受体 |
| 英文关键词: Fibroblast growth factor-inducible 1 4 Non-small-cell lung cancer Epidermal growth factor receptor |
| 基金项目:国家自 然科学基金项目 (811 72224) |
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| 中文摘要: |
| 目的： 探讨成纤维细胞生长因 子诱导 14(Fn1 4)在表皮生长因子受体(EGFR)外显子 19 缺失的非小细胞肺癌(NSCLC)组织中
的表达及其临床意义。 方法： 选择 2010 年 9 月 至 2013 年 11 月 第四军医大学唐都医院收治的 1 25 例 原发性 EGFR 外显子 19 缺
失的 NSCLC 组织及与 之相对应的 30 例 正常肺组织为研究对象， 应用 免疫组化法检测和比较其 Fn14 的表达， 分析 Fn14 的表达
与 原发性 EGFR 外显子 19 缺失的的 NSCLC 临床病理特征的关系。结果： Fn14 阳性表达主要定位于胞膜和胞质中。在 125 例原发
性 EGFR 外显子 19 缺失的 NSCLC 组织中， Fn14 的阳性表达率为 100%，显著高于正常肺组织(P<0.001)。 鳞癌和腺癌 NSCLC 组
织中 Fn14 的阳性表达率比较无统计学差异(P=0.1 06)； 不同 病理分化程度、不同 TNM 分期的 NSCLC 组织中 Fn14 的阳性表达率
比较均具有显著性差异(P=0.000、P=0.000)。 Fn14 蛋白的表达与 EGFR 外显子 19 缺失的 NSCLC 的淋巴结转移状态、肿瘤大小以
及肿瘤解剖学分类均显著相关(P=0.000、 P=0.029、 P=0.000、P=0.026)，而与 患者的性别、年龄、吸烟史均无关(P=0.816、 P=0.122、P=0.
816)。 结论： Fn14 在原发性 EGFR 外显子 19 缺失的 NSCLC 中呈异常高表达， EGFR 外显子 19 缺失突变很可能通过上调 Fn14 通
路， 促进 NSCLC 的发生和发展。 |
| 英文摘要: |
| Objective:To investigate the expression of fibroblast growth factor-inducible 14 (Fn14) in NSCLC tissues with
deletion of EGFR exon 1 9 and its correlation with clinicopathological features.Methods:1 25 NSCLC tissues with primary deletion of
EGFR exon 19 and 30 corresponding normal lung samples were chosen between September 201 0 and November 201 3 in
TangduHospital, Fourth Military Medical University, and Fn1 4 was detected in these samples and the relationships of Fn1 4 expressional
rate in these cancer samples with the pathological grade and clinical stage were analyzed.Results:The expression of Fn14 was mainly
located in cell membrane and cytoplasm. In 125 NSCLC EGFR1 9 deletion samples, the expression rate of Fn1 4 protein is 1 00%, which
showed extremely significance compared with the corresponding normal lung tissue (P < 0.001 ). There was no statistical difference of
Fn1 4 positive expression between the squamous carcinoma group and the adenocarcinoma group (P = 0.106); while there were very
significant difference of Fn14 positive expression in the different pathological grade and TNM stage of NSCLC tissues (P=0.000, P=0.
000). There also was significant correlation of the Fn1 4 protein expression with TNM stages, lymph node metastasis status, tumor size,
and tumor location groups of NSCLC with EGFR 19 deletion (P=0.000, P=0.029, P=0.000, P=0.026). However, there was no significant
correlation of Fn1 4 expression with the gender, age and smoking history groups (P=0.816, P=0.122, P=0.816).Conclusion:The Fn14
proteins are highly expressed in NSCLC tissues with primary deletion of EGFR exon 1 9, and EGFR exon 1 9 deletion mutation might be
the causing reason raising Fn1 4 pathway to promote occurrence and development of NSCLC |
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