| 张正华 侯凯生 谢 芳 金重华 洪洁艳 卫海民 吴学勇.XPD和ECC1 基因多态性与进展期结直肠癌患者铂剂为基础化疗方案
治疗的毒副作用 *[J].现代生物医学进展英文版,2015,15(6):1046-1049. |
| XPD和ECC1 基因多态性与进展期结直肠癌患者铂剂为基础化疗方案
治疗的毒副作用 * |
| Role of Xeroderma Pigmentosum D and Excision Cross Repair CrossComplementing Gene 1 Polymorphism in the Occurrence of Side Effects forAdvanced Colorectal Cancer Patients with Treatment of Platinum BasedChemotherapy |
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| DOI： |
| 中文关键词: 结直肠癌 着色性干皮病基因 D 剪切修复交叉互补基因 l 化疗 不良反应 |
| 英文关键词: Colorectal cancer Xeroderma Pigmentosum D Excision Repair Cross- Complementing 1 Chemotherapy Side effect |
| 基金项目:上海市静安区十百千人才建设工程（ 201006B003） |
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| 中文摘要: |
| 目的： 探讨着色性干皮病基因 D （ ， ） 和剪切修复交叉互 补基因 l （
， ）多 态性基因 型与 以铂类为基础的化疗方案治疗结直肠癌的毒副 作用的关系。 方法： 采用 聚合酶链
反应 -- 限制 性片段长度多 态性 (Polymerase Chain Reaction- Restriction Fragment Length Polymorphism， PCR-RFLP)分析方法，对我
院 2010 年 12 月 至 2013 年 12 月 应用 含奥沙利 铂方案治疗 的 42 例汉族进展期结直肠癌患者的 和 XRCCl 的多 态性基因 型
进行分析， 比较不同 基因 型与 临床病理因 素及化疗 不良反应的关系。 结果： 、 的单核苷酸多 态性 (Single Nucleotide
Polymorphism， SNP)分布与 年龄、性别、淋巴转移、肿瘤的部位、化疗史、分化程度、器官转移个数差异无统计学意义(P＞ 0.05)；
基因 型中， 其中 AA 基因 型以骨髓抑制、恶心呕吐为 主， AG 基因 型以腹泻及肝肾损伤为 主， GG 基因 型以神经毒性及口 腔黏膜炎
为 主， 差异有统计学意义（ P＜ 0.05）； 基因 型中， LG 基因 型以骨髓抑制 、恶心呕吐及腹泻等症状为 主， LL 基因 型以肝肾损
伤、神经毒性及口腔黏膜炎为主， 差异有统计学意义（ P＜ 0.05）。 结论： 和 的基因 型可能与 结直肠癌铂类药物化疗的不
良反应有关。 |
| 英文摘要: |
| Objective:To investigate role of Xeroderma Pigmentosum D and Excision Cross Repair Cross Complementing Gene 1
polymorphism in the occurrence of side effects for advanced colorectal cancer patients with treatment of platinum based chemotherapy.Methods:The and gene polymorphism of 42 cases of Han patients with advanced colorectal cancer who were treated by
programs with oxaliplatin in our hospital from 201 0 December to 201 3 December were analysed by polymerase chainreaction-restriction
fragment length polymorphism (PCR-RFLP). The relationship among different genotypes and clinical pathological factors and side effects
of chemotherapy were analyzed.Results:There was no significant difference in the age, gender, lymphatic metastasis, tumor location,
history of chemotherapy, differentiation, and the number of organ metastasis between single nucleotide polymorphism (SNP) distribution
of and (P>0.05). Of the genotype of , AA was related to the bone marrow suppression, nausea and vomiting,diarrhea;
AG to liver injury; GG to neurotoxicity and oral mucositis; the differences were statistically significant (P < 0.05). Of genotype,
LG was related to bone marrow suppression, nausea, vomiting and diarrhea and other symptoms; LL to liver and kidney damage,
neurotoxicity and oral mucositis; the differences were statistically significant (P<0.05).Conclusion:Genotypes and may be
associated with the occurrence of side effects for advanced colorectal cancer patients with platinum based chemotherapy. |
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