| 翟文慧 1 黄志刚 1 冯 聪 2 李 蓓 2 黎檀实.大气细颗粒污染物 PM2.5 浓度及对肺上皮细胞炎性因子的影响[J].现代生物医学进展英文版,2015,15(6):1028-1031. |
| 大气细颗粒污染物 PM2.5 浓度及对肺上皮细胞炎性因子的影响 |
| Atmospheric Fine Particulate Pollutants Concentrations of PM2.5 and itsEffects on Inflammatory Factors in Pulmonary Epithelial Cells |
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| DOI： |
| 中文关键词: 细颗粒物 肺上皮细胞 IL-6 TNF-alpha |
| 英文关键词: PM2.5 Pulmonary epithelial cells IL-6 TNF-alpha |
| 基金项目: |
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| 中文摘要: |
| 目的： 研究大气细颗粒污染物（ PM2.5）浓度及对肺上皮细胞（ A549 细胞）炎性因子的影响。 方法： 测定 2013 年 1 月 至 2013
年 12 月 北京市某城区 PM2.5 浓度， 比较不同 PM2.5 浓度对 A549 细胞炎性因子 IL-6、TNF-alpha 表达水平的影响。 结果： 北京市细
颗粒污染物 PM2.5 日 均值春季、夏季、秋季、冬季分别 为 174.3 ug/m3、 143.5 ug/m3、 166.7 ug/m3、 189.6 ug/m3， 四季超标率差异无统
计学意义（ P>0.05）； 大气细颗粒污染物 PM2.5 对肺上皮细胞 IL-6、TNF-alpha 的影响， 春季、夏季、秋季、冬季四季之间 差异无统计学
意义（ P>0.05）； 随着 PM2.5 浓度升高 IL-6、 TNF-alpha 表达水平升高， 差异有统计学意义（ P<0.05）;随着染毒时间延长 IL-6、 TNF-alpha 表
达水平升高， 差异有统计学意义（ P<0.05）。 结论： 大气细颗粒污染物浓度升高会使肺上皮细胞炎性因 子表达增强。 |
| 英文摘要: |
| Objective:To explore the atmospheric fine particle pollution (PM2.5) concentrations and its effects on inflammatory
factors in pulmonary epithelial cells (A549 cells).Methods:PM2.5 concentration were tested from January 2013 to December 2013 in
Beijing,compared expression level of inflammatory factors IL-6, TNF-alpha in A549 cells among different PM2.5 concentrations.Results:Daily average values of Beijing PM2.5 fine particulate pollutants in spring,summer, autumn and winter, were 174.3 ug/m3, 143.5 ug/m3,
166.7 ug/m3, 1 89.6 ug/m3, respectively. Exceed the standard rate had no significant difference among the four seasons(P>0.05); influence
of atmospheric fine particles PM2.5 pollutants on pulmonary epithelial cells IL-6, TNF-alpha among spring, summer, autumn and winter
were no significant differences (P>0.05); The IL-6,TNF-alpha expression levels increased with PM2.5 concentration increasing, the
difference was statistically significant (P <0.05), the IL-6,TNF-alpha expression levels increased with the extension of exposure time, the
difference statistically significant (P <0.05).Conclusion:The increase of atmospheric fine particulate pollutant concentration can make
expression of inflammatory cytokines make the lungepithelial cells and inflammatory factor expression enhance. |
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