| 蔺会春 熊金升 刘 清 元亮亮 梁 鹏.PGS 支架的合成、特性及在生物医学中应用的研究进展[J].现代生物医学进展英文版,2015,15(5):976-981. |
| PGS 支架的合成、特性及在生物医学中应用的研究进展 |
| Synthesis, Properties and Biomedical Applications ofPoly(Glycerol Sebacate) |
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| DOI： |
| 中文关键词: 组织工程支架 聚癸二酸甘油酯 生物相容性 |
| 英文关键词: Tissue engineering scaffold Poly (glycerol-sebacate) biocompatibility |
| 基金项目:国家自 然科学基金项目（ 31 040033）； 黑龙江省自然科学基金项目（ D201081） |
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| 中文摘要: |
| 聚癸二酸甘油酯（ PGS）是一种生物可降解的高分子聚合弹性体，因 其良好的性能，在许多 生物医学研究中应用 广泛。 PGS 支
架的机械性能与 机体软组织相似， 依从性好，降解时以表面侵蚀的方式降解， 不 伴有膨胀或变形， 周 围 组织炎症反应、纤维变性
轻， 与多 种细胞相容性好。基于 PGS 良好的性能， 主要应用 于软组织替代和软组织工程， 比如心肌、血管、神经、软骨、视网 膜、鼓
膜，另 外也有用 于药物转运载体、组织粘附材料的研究。 |
| 英文摘要: |
| Poly(glycerol sebacate) (PGS) is a biodegradable polymer increasingly used in a variety of biomedical applications because ofits good performance. PGS is an elastomeric polymer with mechanical properties similar to human tissues, which allows mechanical compliance with tissue and enables facile surgical handling of the polymer. Especially important for the present application, PGS degrades through a surface erosion process that results in loss of mass with no detectable swelling or change in the geometry of the bulk
polymer. Recent studies demonstrate the in vitro biocompatibility of PGS with 3T3 human fibroblasts, baboon primary endothelial progenitor cells and smooth muscle cells, rat Schwann cells, and mouse retinal progenitor cells. In vivo studies have shown that PGS causes
less inflammation and fibrosis than poly (lactide-co-glycolide), a well-studied and widely used biomaterial, and in contrast to poly(lactide-co-glycolide), PGS does not induce a foreign body giant cell response. |
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