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动脉粥样硬化（ atherosclerosis， AS）与心脑血管疾病及周围血管疾病等多种疾病的发病关系密切，而 AS 的慢性炎症性特征已被广泛认可，从早期内皮功能紊乱到最终的斑块破裂，炎性进程伴随于 AS 形成的各个阶段。核因子 -资B（ NF-资B）作为调控炎症信号的重要转录因子，通过调节细胞因子、趋化因子、粘附分子、免疫受体、氧化应激相关酶等一系列特异基因的表达而参与 AS 的病理过程，并在细胞凋亡和细胞增殖等方面发挥着重要的作用，是 AS 形成及防治相关研究中的重要靶点。本文通过概述近年来关于 NF-资B 通路的信号传导在 AS 形成中的作用，回顾本通路相关药物的研究进展，旨在探讨 NF-资B 在动脉粥样硬化研究中所面临的问题，为以 NF-资B 为靶点的抗 AS 药物研究提供理论参考。

英文摘要:

Atherosclerosis (AS) is closely related to cardiovascular and cerebrovascular diseases. It is accepted that chronic inflammatory reaction exists in each process which includes the early phase of endothelial dysfunction and the late phase of plaque rupture. NF-资B, as an important transcription factor in Inflammatory signals regulation, participates in the pathological process of AS by influencing cytokines, chemokines, adherence factors, immune receptors and Oxidative stress related enzymes expression. It also plays important roles in cell apoptosis and proliferation. Therefore, NF-资B is a significant target for prevention and treatment of AS. In this study, we give an overview of the mechanism of NF-资B signaling pathway in AS formation and the research progress of this pathway in order to explore difficulties faced in AS reasearch about NF-资B signaling pathway, and then to provide theoretical basis for development of new antiatherosclerotic drugs.

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