| 刘建华 李琛 支学军 冯平 郑立卿 赵建清 张秀珑 张志华.双水平气道正压通气对 88 例重叠综合征患者的临床疗效[J].现代生物医学进展英文版,2015,15(5):922-925. |
| 双水平气道正压通气对 88 例重叠综合征患者的临床疗效 |
| Clinical Effects of Biphasic Positive Airway Pressure Ventilation on 88 Casesof Patients with Overlap Syndrome |
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| DOI： |
| 中文关键词: 双水平气道正压通气 重叠综合症 慢性阻塞性肺疾病 阻塞性睡眠呼吸暂停低通气综合征 |
| 英文关键词: Biphasic positive airway pressure(BiPAP) Overlap syndrome Chronic obstructive pulmonary disease Obstructive sleep
apnea and hypopnea syndrome |
| 基金项目:河北省医学科学研究重点课题（ 20120159） |
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| 中文摘要: |
| 目 的： 探讨双水平气道正压通气（ BiPAP）治疗重叠综合征（ OS）患者的临床疗效。 方法： 选取 2012 年 7 月 -2014 年 2 月 本院
收治的 88 例 诊断为 重叠综合征的患者， 随机分成实验组与对照组，对照组 43 例 ， 给予常规药物治疗； 实验组 45 例 ，在常规药物
治疗的基础上辅以双水平气道正压通气治疗 ，对两组治疗 前后的监测结果进行比较分析。 结果： 治疗 后，实验组患者在不同时间
点上 pH 和 PaO2 高于对照组， PaCO2、呼吸暂停指数 (AHI) 、睡眠紊乱指数、最长呼吸暂停时间 以及病死率和不良反应发生率均低
于对照组，差异均有统计学意义(均 P＜ 0.05)。 结论： 采用 BiPAP 治疗 OS 患者， 能够有效降低患者病死率、减少不良反应发生率，
并改善患者呼吸情况，提高睡眠质量。 |
| 英文摘要: |
| Objective:To study the clinical effect of Biphasic positive airway pressure (BiPAP) on patients with overlap syndrome
(OS).Methods:To select 88 patients with overlap syndrome who were treated in the hospital from July 2012 to February 201 4 and randomly divide them into the control group (43 cases) and the experimental group (45 cases). Control group received conventional drug
treatment and experimental group were treated with Biphasic positive airway pressure on the basis ofconventional drug therapy. The monitoring results of with the two groups were analyzed and compared before and after treatment.Results:After the treatment, pH and PaO2 in
experimental group at different time points were higher than those in control group. And the PaCO2, AHI, sleep disturbance index, the
longest time of apnea, the mortality and the incidence of adverse reaction were lower than those in control group with significant differences (all P<0.05).Conclusion:BiPAP therapy can effectively reduce the mortality and the incidence of adverse reaction, and improve the
breathing and sleep quality in patients with overlap syndrome. |
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