| 赵莉芳 郑宏超 缪培智 徐亚伟 顾水明.ACE、 CYP1 1B2 基因多态性与慢性心力衰竭患者醛固酮脱逸的关系[J].现代生物医学进展英文版,2015,15(5):900-904. |
| ACE、 CYP1 1B2 基因多态性与慢性心力衰竭患者醛固酮脱逸的关系 |
| The Relationship between ACE, CYP11 B2 Gene Polymorphism and Escapeof Aldosterone in Patients with Chronic Heart Failure |
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| DOI： |
| 中文关键词: 醛固 酮脱逸 慢性心力衰竭 基因 多 态性 CYP11 B2 ACE |
| 英文关键词: Aldosterone escape Chronic heart failure Gene polymorphism CYP11 B2 ACE |
| 基金项目:上海市科技局基金项目（ SHXH2011 39） |
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| 中文摘要: |
| 目的： 研究 CYP11 B2-344C/T(醛固酮合成酶)及 ACEI/D(血管紧张素转化酶)基因 多 态性与慢性心力衰竭(CHF)患者实施 ACEI
治疗后出现醛固酮脱逸表现的关系。 方法： 回顾分析 2008 年 10 月 至 2012 年 10 月 我科收治的 252 例 CHF 患者， 全部患者应用
ACEI 治疗 3 月 ，醛固酮在基线以上为醛固 酮脱逸，依据此标准将患者分为研究组(脱逸组， n=86)与对照组(非脱逸组， n=1 66)，依据
PCR(聚合酶链反应)及 RFLP(片 段长度限制多 态性)等方法分别检测两组 CYP11 B2 及 ACE 基因型， 比较两组基因型频率的分布。
结果： 252 例 患者中， 共 86 例 出现醛固酮脱逸， 发生率为 34.1%。 全部受试患者 CYP11 B2 基因型及 ACE 基因型频率与 Weinberg-Hardy 平衡均相符(P 均 >0.05)。 研究组 ACE I/D 三种基因型的组间分布与对照组相较， 无统计学差异(P>0.05)； CYP1 1B2 基
因 TT 型的频率与对照组相较，呈明 显统计学差异(P<0.05)， 等位基因 C/T 频率的组间分布同 对照组相较， 亦呈明显差异(P<0.05)。
研究组 ACEI/D 的基因 多 态性及 CYP11 B2-344C/T 的多 态性中，基因型联合组间 分布与对照组相较， 无统计学差异(P>0.05)。 结
论： ACE 基因 多 态性与 CHF 患者 ACEI 治疗后出 现醛固酮脱逸无关， CYP11 B2 基因 T 等位基因 及 TT 基因型多 态性可能是 CHF
患者 ACEI 治疗后发生醛固酮脱逸的高危因素。 醛固酮脱逸时， ACE、CYP1 1B2 基因 不具有协同 效果。 |
| 英文摘要: |
| Objective:To study the relationship between CYP11 B2-344-c/T(aldosterone synthase) and ACEI/D(angiotensin converting enzyme gene polymorphism and patients with chronic heart failure (CHF) after the implementation of ACEI treatment aldosterone
extruding performance.Methods:252 patients with CHF admitted in our department from October 2008 to October 201 2 were, retrospectively, analyzed. All the patients were treated by ACEI for 3 months. Aldosterone above baseline was considered as aldosterone escape,
patients were divided into research group (extruding group, n=86) and control group (non-extruding group, n=166) according to this standard, PCR (polymerase chain reaction) and RFLP (fragment length polymorphism) method were used to detect and compare the
CYP11 B2 and ACE genotype distribution.Results:In 252 cases of patients, a total of 86 cases (34.1 %) with aldosterone extruding were
observed, All the patients' CYP1 1B2 gene type and ACE genotype frequency and Weinberg-Hardy balance were consistent (P>0.05). No
significant difference was found in the three ACE I/D genotype distribution between research group and control group (P>0.05); the TT
frequency of CYP1 1B2 genotype, allele C/T frequency distribution of research group were significantly different from that of the control
group(P<0.05). No statistical difference was observed in the team of ACEI/D gene polymorphism and CYP11 B2-344-c/T polymorphism,
genotype distribution between the joint groups compared with control group (P>0.05).Conclusion:ACE gene polymorphism had no correlation with the aldosterone escape after ACEI treatment of CHF patients, T allele and genotype TT of CYP11 B2 gene polymorphisms
may be risk factors of aldosterone escape after ACEI treatment, ACE, CYP1 1B2 gene hadn't synergistic effect during the aldosterone escape. |
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