| 杨红霞 贺晓燕 齐晓辉 张彦丽 戴剑峰.硝苯地平控释片联合替米沙坦对老年高血压患者动态血压及左室舒张功能的影响[J].现代生物医学进展英文版,2015,15(5):866-869. |
| 硝苯地平控释片联合替米沙坦对老年高血压患者动态血压及左室舒张功能的影响 |
| Effect of Nifedipine Controlled Release Tablets plus Telmisartan on theAmbulatory Blood Pressure Monitoring and Left Ventricular DiastolicFunction of Elderly Patients with Hypertension |
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| DOI： |
| 中文关键词: 硝苯地平控释片 替米沙坦 老年高血压 动态血压检测 心室舒张功能 |
| 英文关键词: Nifedipine Controlled Release Tablets Telmisartan Elderly hypertension ABPM Ventricular diastolic function |
| 基金项目:国家自 然科学基金项目 (811 70400) |
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| 中文摘要: |
| 目 的： 研究硝苯地平控释片 联合替米沙坦对老年高血压患者动态血压以及左室舒张功能的影响。 方法： 选择我院 2012 年 12
月 至 2013 年 11 月 收治的轻、中度老年高血压合并左室舒张功能不全的患者 84 例为 研究对象， 并将其随机分为两组。对照组给
予硝苯地平控释片 30~60 mg/d， 观察组在对照组的基础上，加用 替米沙坦 40 mg/d，降压未达疗 效者， 改为 80 mg/d，疗程 12 周 。 期
间 观察和比较两组患者的动脉血压波动情况、左心室舒张功能及疗效。 结果： 对高血压的控制， 观察组总有效率显著高于对照组
(P<0.05)， 显效率高于对照组， 但无统计学意义 (P>0.05)。 动态血压监测及血压负荷结果提示两组治疗后的 24 h 收缩压平均值
(24hmSBP)、24 h 舒张压平均值(24hmDBP)、日 间收缩压平均值(dmSBP)、日 间舒张压平均值(dmDBP)、夜间收缩压平均值(nmSBP)、
夜间舒张压平均值(nmDBP)均显著低于治疗 前， 且观察组显著优于对照组(P<0.05)。两组的左心室射血分数(LVEF)、左心室收缩末
期内 径(LVESD)、左心室舒张末期内 径(LVEDD)、舒张期左室后壁厚度(LVPWD)、舒张期室间 隔厚度(IVST)水平均较治疗 前有所
改善，但差异无统计学意义(P>0.05)； 观察组各指标水平优于对照组， 但差异亦无统计学意义(P>0.05)。 结论： 硝苯地平控释片 联合
替米沙坦治疗 老年高血压有助于更加有效地控制其动态血压波动，且在一定程度上可改善左心室舒张功能。 |
| 英文摘要: |
| Objective:To investigate the effect of Nifedipine Controlled Release Tablets with Telmisartan Tablets on the ABP and
left ventricular diastolic function of elderly hypertension.Methods:84 mild or moderate elderly hypertension patients from December
2012 to November 201 3 were divided into two groups randomly. The patients in control group took Nifedipine Controlled Release
Tablets at 30~60mg/d. The observation group were dosed with 40 mg/d of Telmisartan Tablets. If the observation group failed to see the
satisfactory drop, the dose of Telmisartan Tablets was adjusted to 80 mg/d. The whole research lasted for 1 2 weeks. The ABP and left
ventricular diastolic function were observed and recorded during the research.Results:The total efficient rate of observation group was
significantly higher than t the counterparts of control group (P<0.05). The excellent rate of observation group was higher than that of the
other group(P>0.05). All the results of ABPM indexes and blood pressure load (including 24hmSBP, 24hmDBP, dmSBP, dmDBP, nmSBP,
nmDBP) showed that both groups could control the fluctuation of blood pressure, while the observation group was superior to the control
group(P<0.05). The results of left ventricular diastolic function (including LVEF, LVESD, LVEDD, LVPWD, IVST) indicated that both
therapeutic schedule could improve the left ventricular diastolic function at certain extent. However, the differences between the two
groups did not have statistical significance.Conclusion:To treat elderly hypertension with Nifedipine Controlled Release Tablets and
Telmisartan Tablets could effectively control the fluctuation ofblood pressure and improve left ventricular diastolic function to some extent. |
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