| 马水根 杨进 廖革望 史彩霞 金志红 眭鸿颖 陶光实.CCR9 和CCL25 蛋白在上皮性卵巢癌中表达及临床意义[J].现代生物医学进展英文版,2015,15(4):727-730. |
| CCR9 和CCL25 蛋白在上皮性卵巢癌中表达及临床意义 |
| Expressions of CCR9 and CCL25 in Epithelial Ovarian Carcinomaand Clinic Significance |
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| DOI： |
| 中文关键词: CCR9 CCL25 上皮性卵巢癌 组织芯片 免疫组化 |
| 英文关键词: CCR9 CCL25 Epithelial ovarian cancer Tissue microarray Immunohistochemistry |
| 基金项目:湖南省自然科学基金项目（14JJ7060） |
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| 中文摘要: |
| 目的：探讨CCR9 和CCL25 蛋白在不同卵巢组织中的表达及其与上皮性卵巢癌患者临床病理因素之间的关系。方法：通过
组织芯片结合免疫组织化学法检测78 例上皮性卵巢癌组织和30 例正常卵巢组织中CCR9 和CCL25 表达水平，结合上皮性卵巢
癌病人的临床病理资料，进行统计分析。结果：CCR9 和CCL25 在上皮性卵巢癌中高表达，在正常卵巢组织中低表达，二者的表达
与上皮性卵巢癌的组织类型、患者年龄无显著相关(P>0.05)，而与淋巴结转移、组织学分级和临床分期有显著相关(P<0.05)；上皮
性卵巢癌组织中CCR9 与CCL25 表达相关(P<0.05)。结论：CCR9 和CCL25 在上皮性卵巢癌的发生发展中可能起重要作用，二者
可能是上皮性卵巢癌治疗的一个潜在的分子靶点。 |
| 英文摘要: |
| Objective:To investigate the expressions of CCR9 and CCL25 protein in different ovarian tissues and the relationship
between their expression and clinical pathological factors of epithelial ovarian cancer patients.Methods:Tissue microarray and immunohistochemistry
were used to detect the expressions of CCR9 and CCL25 in 78 cases of epithelial ovarian cancer and 30 cases of normal
ovarian tissues. The relationship between their expression and clinical pathological factors of epithelial ovarian cancer patients was statistically
analyzed.Results:The expressions of CCR9 and CCL25 in epithelial ovarian cancer was high, but in normal ovarian tissue their
expression was low. The expressions of CCR9 and CCL25 did not correlate with histological type and age of patients (P>0.05), while
there was a positive correlation between the expressions of CCR9 and CCL25 with lymphnode metastasis, histological grade and clinical
stage(P<0.05). The expression of CCR9 was associated with that of CCL25(P<0.05).Conclusion:CCR9 and CCL25 may play an important
role in the development of epithelial ovarian cancer, which may be a potential molecular target for the treatment of epithelial ovarian
cancer. |
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