| 郭馨云 张荣 乔够梅 刘彩虹.14-3-3θ蛋白在乳腺癌中的表达和预后的临床研究[J].现代生物医学进展英文版,2015,15(3):433-436. |
| 14-3-3θ蛋白在乳腺癌中的表达和预后的临床研究 |
| Expression and Prognosis of Clinical Study of 14-3-3θProteinin Breast Cancer |
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| DOI： |
| 中文关键词: 乳腺癌 14-3-3θ 免疫组化 预后 |
| 英文关键词: Breast cancer 14-3-3θ Immunohistochemistry Prognosis |
| 基金项目:国家自然科学基金项目(81170400) |
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| 中文摘要: |
| 目的：研究14-3-3θ蛋白在人乳腺癌中的表达和预后的临床意义。方法：在210 例人乳腺癌组织样本中，通过免疫组化的方
法检测14-3-3θ蛋白的表达情况，并分析其表达与乳腺癌临床病理学特征间的相关性及与患者总生存期的关系。结果：在210 乳
腺癌组织中，14-3-3θ蛋白的阳性表达为64.3%。卡方检验分析表明，14-3-3θ蛋白的表达与患者的发病年龄、肿瘤大小、组织分化
程度以及HER2 状态均没有相关性（P > 0.05）；而14-3-3θ蛋白高表达与高TNM 分期（P = 0.013）、淋巴结转移（P < 0.0001）以及
ER阴性（P = 0.006）存在相关性。Spearman 相关性分析检测发现，14-3-3θ蛋白高表达与高TNM 分期（r = -0.187, P = 0.006）、阳性
淋巴结转移（r = -2.272, P < 0.0001）呈正相关，而与ER 阳性状态（r = -0.046, P = 0.003）呈负相关。Kaplan-Meier 分析结果显示：伴
有14-3-3θ蛋白高表达患者的DFS 与OS 明显少于14-3-3θ蛋白低表达的患者，log-rank 检验提示P值分别为0.0379 和0.0037，
具有统计学意义。结论：在乳腺癌组织中，14-3-3θ作为癌基因表达增加，与乳腺癌的发展和转移发生呈正相关，14-3-3θ可以作为
乳腺癌患者预后和疾病复发的检测指标。 |
| 英文摘要: |
| Objective:To investigate the expression and prognosis of clinical significances of 14-3-3θprotein in human breast
cancer.Methods:Expression status of 14-3-3θwas detected by immunohistochemistry in 210 cases of human breast cancer specimens.
Expressions, correlations and prognosis of 14-3-3θwere analyzed.Results:In 210 cases of breast cancer specimens, the positive
expression of 14-3-3θwas 64.3%. The chi square test suggested that 14-3-3θexpression was not correlated with age, tumor size,
histology, or HER2 status (P>0.05), while which was correlated with TNM stage, lymph node metastasis, and ER status (P<0.05).
Correlation analysis suggested that 14-3-3θexpressions were positively correlated with advance TNM stage (r = -0.187, P = 0.006),
positive lymph node metastasis (r = -2.272, P < 0.0001), and negative ER status (r = -0.046, P = 0.003). Breast cancer patients with high
14-3-3θexpression had a shorter overall survival and a higher rate of recurrence than those with low 14-3-3θexpression (P = 0.0379 or
0.0037).Conclusion:In breast cancer, expressions of 14-3-3θincreased and were correlated with tumor progression. 14-3-3θmay serve
as a candidate prognostic biomarker in breast cancer progression. |
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