| 刘雅东 富路 刘佳 于秀峰 杨静.生长分化因子-15 在急性冠脉综合征中的临床研究[J].现代生物医学进展英文版,2015,15(2):391-393. |
| 生长分化因子-15 在急性冠脉综合征中的临床研究 |
| Clinical Studies of Growth Differentiation Factor-15 in Acute CoronarySyndrome |
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| DOI： |
| 中文关键词: 生长分化因子-15 急性冠脉综合征 临床研究 预后 |
| 英文关键词: Growth differentiation factor-15 Acute coronary syndrome Clinical studies Prognosis |
| 基金项目: |
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| 中文摘要: |
| 生长分化因子-15(growth differentiation factor-15,GDF-15)是转化生长因子超家族的成员之一。近年来有实验室及临床研究
发现，生长分化因子-15 在心肌缺血或缺血/ 再灌注损伤时可高表达，并减少心肌细胞坏死的数量，抑制缺血心肌细胞的凋亡。在
心肌压力超负荷的情况下，生长分化因子-15 高表达或给予外源性生长分化因子-15 可抑制心肌肥厚及心脏扩大，保护心功能。
而在临床研究中发现急性冠脉综合征的患者生长分化因子-15 增高，与部分心血管的危险因素存在相关性，对患者的预后有提示
作用。 |
| 英文摘要: |
| Growth differentiation factor-15 (GDF-15)is a member of the transforming growth factor-茁superfamily. Recent
experimental research and clinical studies have found that GDF-15 is highly expressed in myocardial ischemia or ischemia/reperfusion
injury, which can reduce myocardial necrosis and apoptosis. In the condition of pressure overload, GDF-15 over expression, or
exogenous GDF-15, can inhibit myocardial hypertrophy and dilation, appearing to have a cardio-protective effect. Some clinical studies
show that the circulating level of GDF-15 is significantly higher in patients with acute coronary syndrome, GDF-15 may provide
predictive information for patients. |
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