| 李季杨 蒋梦婉 王宏达 何秀萍.DKK3 在上皮性卵巢癌中表达的初步探索[J].现代生物医学进展英文版,2015,15(2):308-311. |
| DKK3 在上皮性卵巢癌中表达的初步探索 |
| The Preliminary Study on the Expression of DKK3 in Epithelial OvarianCancer |
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| DOI： |
| 中文关键词: DKK3 卵巢癌 免疫组织化学 |
| 英文关键词: DKK3 EOC Immunohistochemistry |
| 基金项目: |
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| 中文摘要: |
| 目的：探讨DKK3 表达与卵巢上皮性癌的关系。方法：采用免疫组化法检测不同卵巢组织DKK3 蛋白表达水平，其中88 例
卵巢上皮性癌组织(以下简称卵巢癌组织)、39 例卵巢良性肿瘤组织及46 例正常卵巢组织。结果：DKK3 在正常卵巢组织、卵巢良
性肿瘤及卵巢癌组织的表达有明显差异，差异有统计学意义(P ＜0.05)。而DKK3 表达与上皮性卵巢癌的临床病理分期及分化程
度无关（P＞ 0.05）。结论：DKK3 表达水平下降与卵巢癌有关，DKK3 可作为预测卵巢癌的指标。 |
| 英文摘要: |
| Objective:To investigate the relationship between DKK3 expression and the epithelial ovarian cancer (EOC).Methods:Immunohistochemistry was used to detect the difference of DKK3 protein expression among normal ovarian tissues (n=46),
benign ovarian tumors (n=39), and EOC (n=88). Chi square test and Fisher's exact test were used to inspect the relevance between DKK3
expression level and clinicopathological factors.Results:DKK3 expression level downgraded in ovarian carcinoma (p＜0.05). DKK3
took no responsibility for the clinicopathologic stage and differentiated degree.Conclusion:DKK3 showed decrease in EOC, and that
DKK3 presented a potential predictor to EOC. |
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