| 张映城 赵婧 顾雨芳 张森森 秦志丰.外周血免疫细胞亚群及肿瘤标记物对胃大部切除术后患者预后预测的
应用价值[J].现代生物医学进展英文版,2015,15(2):302-307. |
| 外周血免疫细胞亚群及肿瘤标记物对胃大部切除术后患者预后预测的
应用价值 |
| The Clinical Value of Peripheral Immune Subpopulation Cells and TumorMakers in the Prognostic Prediction of Patients after Subtotal Gastrectomy |
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| DOI： |
| 中文关键词: 胃癌 胃大部切除术 外周血免疫细胞亚群 肿瘤标记物 |
| 英文关键词: Gastric cancer Subtotal gastrectomy Peripheral immune cells Tumor markers |
| 基金项目: |
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| 中文摘要: |
| 目的：探讨外周血免疫细胞亚群及血清肿瘤标记物对胃大部切除术后患者的预后预测的应用价值。方法：应用电化学发光免
疫分析法及流式细胞术分别检测25 例胃大部切除术后患者的相关血清肿瘤标记物(AFP、CEA、CA19-9、CA12-5、CA72-4)及外周
血免疫细胞亚群CD3、NK、CD4、CD8、CD4/CD8，结合长期随访，采用统计学方法分析不同指标之间的相关性及其对胃大部切除
术后患者预后预测的应用价值。结果：胃大部切除术后患者外周血免疫细胞亚群及血清肿瘤指标均存在异常，Mann-Whitney检验
分析显示外周血CD4 T细胞亚群和CEA 呈显著负相关(r= -0.460，P=0.014)。Kaplan-Meier 生存分析显示胃大部切除术后患者
CD4(P=0.021)和CA72-4(P=0.012)水平和患者预后明显相关。多因素Logistic 分析显示CD4(P=0.008)和CA72-4(P=0.010)是影响
胃大部切除术后患者预后的独立危险因素。结论：胃大部切除术后患者免疫细胞亚群及血清肿瘤标记物短期内仍存在异常，高水
平CD4 和低水平CD72-4 与患者预后良好显著相关。 |
| 英文摘要: |
| Objective:To investigate the prognostic value of peripheral immune subpopulation cells and serum tumor makers in
subtotal gastrectomy patients.Methods:By measuring the value of serum tumor makers (AFP, CEA, CA19-9, CA12-5, CA72-4) and
peripheral immune subpopulation cells (CD3, NK, CD4, CD8, CD4/CD8) in 25 subtotal gastrectomy patients with the method of
electrochemiluminescent immunoassay and flow cytometry, we analyzed the correlation between these markers by different statistical
methods and their prognostic value for the patients with the data of long-time follow-up, respectively.Results:Both of the peripheral
immune subpopulation cells and serum tumor markers are abnormal in patients under subtotal gastrectomy. By Mann-Whitney analysis,
we found that the value of peripheral CD4 T cells was negatively associated with CEA (R= -0.460, P=0.014). In addition, the
Kaplan-Meier analysis indicated that the value of CD4 T cells (P=0.021) and CA72-4 (P=0.012) was correlated with the overall survival
of the patients, and these results were further confirmed by the Logistic analysis, CD4(P=0.008) and CA72-4(P=0.010), which suggested
that the value of both are independent risk for the prognosis.Conclusion:Peripheral immune subpopulation cells and serum tumor
markers sustained abnormal in a short period for patients after subtotal gastrectomy, high value of CD4 T cells and low value of CA72-4
may be correlated with better prognosis. |
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