| 吴沛珊 付宜鸣 冯 堃 陈起引 倪少滨.PSA 相关指标对前列腺癌诊断价值的评价及比较研究[J].现代生物医学进展英文版,2015,15(2):291-293. |
| PSA 相关指标对前列腺癌诊断价值的评价及比较研究 |
| vAn Appraisive and Comparative Study on the Prostate Specific Antigenin the Diagnosis of Prostatic Cancer |
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| DOI： |
| 中文关键词: TPSA F/TPSA PSAD 前列 腺癌 ROC 曲线 |
| 英文关键词: Total Prostate Specific Antigen Free/Total Prostate Specific Antigen Prostate specific antigen density Prostatic cancer Receiver operating characteristic |
| 基金项目: |
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| 中文摘要: |
| 目的： 探讨血清总 PSA(TPSA)、 F/TPSA 和 PSA 密度(PSAD)在前列 腺癌(PCa)诊断中的价值， 寻找更准确的前列 腺癌诊断指
标。 方法： 采用化学发光免疫分析法检测前列 腺癌患者(60 例 )和前列 腺增生患者(240 例 )的血清 PSA 水平， 通过 B 超测定患者前
列 腺的体积， 计算 PSAD， 运用 ROC 曲线评价和比较血清总 PSA(TPSA)、F/TPSA 和 PSAD 诊断前列 腺癌的准确性和特异性。 结
果： (1)前列 腺癌患者 TPSA 和 PSAD 值均明显高于前列 腺增生患者(P<0.01),F/TPSA 明 显低于前列 腺增生患者(P<0.01)； (2)TPSA
阈值定为 4 ng/ml 时，诊断前列 腺癌的敏感性、特异性分别 为 56.23%、 80.1 0%。 F/TPSA 阈值定为 0.15 时，诊断前列 腺癌的敏感性、
特异性分别为 88.1 0%、 69.1 0%， PSAD 阈值定为 0.20 时， 诊断前列 腺癌的敏感性、 特异性分别 为 88.60%、88.30%。 结论： TPSA、
F/TPSA 和 PSAD 在前列 腺癌诊断中均有一定的价值， 且 PSAD 诊断前列 腺癌的敏感性、特异性优于 TPSA、 F/TPSA， 是诊断前列
腺癌更为理想的指标。 |
| 英文摘要: |
| Objective:To study the clinical value of TPSA, F/TPSA, PSAD in the diagnosis of prostrate cancer (PCa), and to look
for a more accurate diagnosis indicator of prostate cancer (PCa).Methods:Serum PSA levels were determined by chemiluminescent
immunoassay (CLIA) in 60 patients with prostate carcinoma confirmed by surgery and 240 patients with benign prostatic hyperplasia.
Prostatic volume was measured with B-type ultrasonography and PSAD was calculated. The receiver operating characteristic (ROC)
curve was used to evaluate the diagnostic efficacy of TPSA, F/TPSA and PSAD.Results:(1)TPSA and PSAD levels in patients with
prostatic adenocarcinoma were both significantly higher than those in patients with BPH (P<0.01 ), but F/TPSA was markedly lower(P<0.
01). (2)When TPSA level was of 4 ng/ml or greater, the sensitivity and specificity were 56.23% and 80.10% respectively in the diagnosis
of prostatic adenocarcinoma. When F/TPSA level was 0.15 or greater, the sensitivity and specificity were 88.1 0% , and 69.1 0%
respectively in the diagnosis of. prostatic adenocarcinoma. When PSAD level was 0.20 or greater, the sensitivity and specificity were
88.60% and 88.30% respectively in the diagnosis of prostatic adenocarcinoma.Conclusion:TPSA, F/TPSA and PASD had clinical
significance in the dignosis of prostatic carcinoma, but PSAD was more reliable than TPSA and F/TPSA. which was an ideal marker for
the diagnosis of PCa. |
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