| 于双 薄玉龙 徐咏梅 石伟东 周万华.七氟烷对糖尿病心肌缺血/再灌注损伤的影响[J].现代生物医学进展英文版,2015,15(1):198-200. |
| 七氟烷对糖尿病心肌缺血/再灌注损伤的影响 |
| The Influence of Sevoflurane to Diabetes Myocardial Ischemia/ReperfusionInjury |
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| DOI： |
| 中文关键词: 七氟烷 糖尿病 缺血/再灌注损伤 |
| 英文关键词: Sevoflurane Diabetes mellitus Ischemia/reperfusion injury |
| 基金项目: |
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| 中文摘要: |
| 糖尿病是一种常见病、多发病，严重威胁着人类的健康。现已明确，糖尿病是冠心病发病的一个重要因素。心肌缺血/ 再灌注
（ischemia/reperfusion，I/R）损伤是临床常见的病理过程，同时是冠心病发病及心肌血运重建治疗过程中的核心环节，如何减轻I/R
损伤一直是国际研究热点之一。糖尿病与I/R 损伤对心肌都有损害作用，相关研究证明糖尿病能够进一步恶化I/R 损伤对心肌的
损伤作用。研究表明，缺血预处理（ischemia preconditioning，IPC）可以延缓或减轻心肌I/R 损伤，同时，麻醉药预处理（anesthetic
induced preconditioning，APC）也具有IPC 样的心肌保护作用。其中，七氟烷作为现阶段临床较常用的吸入麻醉药，同样对心肌I/R
损伤具有保护作用。本文就七氟烷对糖尿病心肌I/R 损伤的影响及其机制做一综述。 |
| 英文摘要: |
| Diabetes Mellitus(DM) is a frequently-occurring disease. It's seriously threatening people's health. And it is one of the
important factors to coronary heart disease. Myocardial ischemia / reperfusion (I/R) injury is a common pathological process, and how to
reduce I/R injury has been one of the international hot points. DM and I/R injury both hurt heart function, and related research demonstrates
that DMcan enhance myocardial I/R injury. Studies show that ischemia preconditioning (IPC) can release myocardial I/R injury,
and anesthetic induced-preconditioning (APC) has the same protective effect as IPC. Sevoflurane is one more common inhalational anesthetic,
and has protective effect on myocardial I/R injury, too. This paper is about the influence and mechanismof sevoflurane to diabetes
myocardial ischemia/reperfusion injury. |
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