| 王鹏燕 叶雅静 何进 尹大川.制备大孔径静电纺丝组织工程支架的研究进展[J].现代生物医学进展英文版,2015,15(1):155-159. |
| 制备大孔径静电纺丝组织工程支架的研究进展 |
| A Review for Fabrication of Large Pores in Electrospun Scaffolds forTissue Engineering |
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| DOI： |
| 中文关键词: 静电纺丝 三维支架 大孔径 细胞浸润 |
| 英文关键词: Electrospinning Three-dimensional scaffolds Large pores Cell infiltration |
| 基金项目:国家自然科学基金项目（50801052） |
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| 中文摘要: |
| 研究表明静电纺丝可以制备出模拟细胞外基质的三维结构，其中限制静电纺丝纤维支架应用的问题之一就是纤维排列紧
密导致支架的孔径较小，从而阻碍了细胞的浸入，组织中血管化的形成以及支架与宿主细胞的融合。为了增大支架的孔径，提高
孔隙率，许多研究者提出了相应的策略。本文综述了多种制备大孔径静电纺丝纤维支架的方法，主要包括不同接收装置控制电场
分布、盐粒子/ 聚合物析出法、水浴接收、低温静电纺丝以及激光/ 紫外烧蚀法等，以上的方法都能够有效的增大静电纺丝三维支
架的孔径，进而提高了细胞的浸润性、营养物质的传输以及废物的排出，为静电纺丝纤维支架在组织工程中的应用奠定了基础。 |
| 英文摘要: |
| Research shows that electrospinning method can mimic the configuration of native extracellular matrix. Which limits
the application of electrostatic spinning scaffold are the problems of the tightly packed layers of nanofibers causing smaller pore diameter
and restricting cell infiltration, vascularization in tissue and the fusion of scaffold with the host cell. In order to increase the pore size and
porosity of scaffold, many researchers have put forward a lot of strategies. This paper reviews a various kinds of methods for fabrication
of large pores in electrospun nanofibrous scaffolds, including controlling the electric field, salt particle/polymer leaching, receiving to
bath collector, Low temperature electrospinning and, Laser/UV, irradiation, etc. All the above methods can effectively increase electrostatic
spinning three-dimensional scaffold pore size, thus improving the cell infiltration, the transmission of nutrients and waste, which lay
a foundation for the application of electrostatic spinning fiber scaffolds in tissue engineering. |
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