| 韩瑞旸 武子朝 刘少军 王微慎 李涛 曹玮 杜随勇 贾宗海 张惠丽 李润根.唑来膦酸联合钙尔奇D治疗糖尿病性骨质疏松的临床疗效研究[J].现代生物医学进展英文版,2015,15(1):104-106. |
| 唑来膦酸联合钙尔奇D治疗糖尿病性骨质疏松的临床疗效研究 |
| Efficacy of Zoledronic Acid plus Caltrate Don in the Treatment of DiabeticOsteoporosis |
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| DOI： |
| 中文关键词: 唑来膦酸 钙尔奇D 糖尿病性骨质疏松 临床疗效 |
| 英文关键词: Zoledronic acid Caltrate D Diabetic osteoporosis Clinical effects |
| 基金项目:国家自然科学基金项目(81170400) |
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| 中文摘要: |
| 目的：观察唑来膦酸联合钙尔奇D 治疗糖尿病性骨质疏松症的临床疗效。方法：将120 例糖尿病性骨质疏松患者随机分为
实验组和对照组，实验组60 例予唑来膦酸联合钙尔奇D 治疗，对照组60 例予钙尔奇D 治疗。连续治疗12 个月后，比较两组患者
的骨密度、疼痛评分及不良反应的发生情况。结果：治疗12 个月后，实验组患者的股骨颈、股骨粗隆和腰椎正位的骨密度均较对
照组明显升高，差异有统计学意义(P<0.05)；VAS疼痛评分较对照组显著降低(P<0.05)。治疗过程中，两组均无严重的不良反应发
生。结论：唑来膦酸联合钙尔奇D 治疗糖尿病性骨质疏松临床效果优于钙尔奇D 单药治疗。 |
| 英文摘要: |
| Objective:To investigate the efficacy of Zoledronic acid plus Caltrate D in the treatment of diabetic osteoporosis.Methods:120 patients diagnosed as diabetic osteoporosis were randomly divided into the experimental group and control group, 60 cases
in each group. The control group was treated with Caltrate D and the experimental group was treated with CaltrateD plus Zoledronic acid
for 12 months. Then the BMD points of VAS and untoward effect were compared between two groups.Results:After 12 months' treatment,
the bone mineral density of femoral neck, trochanter, and lumbar spine in the experimental group were significantly higher than
those of the control group (P<0.05), and the scores of VOA was significantly lower than that of the control group (P<0.05). There were no
serious adverse reactions during the treatment.Conclusion:Zoledronic acid plus Caltrate D was more effective than Caltrate D alone in
the treatment of diabetic osteoporosis. |
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