| 冯征1 程少毅1 李小飞1 祖超1 陈召2 卢强1 周勇安1△.纤维支气管镜吸痰对全肺切除术后心衰治疗效果的观察[J].现代生物医学进展英文版,2015,15(1):84-86. |
| 纤维支气管镜吸痰对全肺切除术后心衰治疗效果的观察 |
| The Effects of SputumSuction Treatment by Fiberoptic Bronchoscopyon Patients with Heart Failure after Pneumonectomy |
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| DOI： |
| 中文关键词: 全肺切除术 心衰 纤维支气管镜 吸痰 |
| 英文关键词: Pneumonectomy Heart failure Fiberoptic bronchoscopy Sputumsuction |
| 基金项目:陕西省自然科学基金项目（2012JM4022） |
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| 中文摘要: |
| 目的：探讨规律纤维支气管镜吸痰对全肺切除术后心衰的治疗效果。方法：选取唐都医院胸外科于2012 年1 月至2014 年1
月行开胸全肺切除术，且术后并发心衰的患者184 例进行前瞻性随机对照研究，将所选患者分为研究组(96 例)和对照组(88 例)，
前者除常规心衰治疗外，每天至少1 次使用纤维支气管镜吸痰，必要时可根据痰量增加吸痰次数；后者仅采用利尿、强心、扩血管
等常规疗法，比较两组患者的心指数、呼吸频率、动脉血气分析等指标，同时测定和比较两组患者治疗后72 h的血浆脑钠肽浓度。
结果：治疗后1 h，对照组患者的心指数由(2.7± 0.2) L/min·m2 升高至(3.1± 0.3) L/min·m2，呼吸频率由(35.4± 2.9)次/ 分降至
(21.3± 2.5)次/分，PaO2由(57.4± 3.9) mmHg升至(60.3± 3.4) mmHg，SaO2由(83.5± 7.1)%升至(86.3± 3.7)%；研究组患者的心指数
由(2.8± 0.1) L/min·m2升高至(3.5± 0.2) L/min·m2，呼吸频率由(34.2± 3.1)次/ 分降至(19.2± 2.2)次/分，PaO2由(56.5± 4.8) mmHg
升至(66.2± 7.1) mmHg，SaO2由(84.5± 6.5)%升至(91.6± 3.5)%，差异具有统计学意义(P<0.05)，研究组患者治疗后的以上指标水平
均明显优于对照组(P<0.05)。治疗后24 h内，79.2%的研究组患者咳嗽、咳痰及肺部湿罗音基本缓解，对照组患者以上症状、体征的
缓解率为47.7%，差异具有统计学意义(P<0.05)。治疗后72 h，研究组患者的血浆脑钠肽浓度显著低于对照组患者(576.3± 77.6 vs
894.6± 86.5，P<0.01)。结论：支气管镜吸痰有助于改善全肺切除术后心衰患者的心肺功能。 |
| 英文摘要: |
| Objective:To explore the effects of sputum suction treatment by fiberoptic bronchoscopy on patients with heart failure
after pneumonectomy.Methods:120 patients who had accepted pneumonectomy and underwent postoperative heart failure in Tangdu
hospital from January 2012 to January 2014 were selected. All the patients were divided into study group and control group equally. The
patients in study group accepted sputum suction treatment by fiberoptic bronchoscopy and classic therapy including diuretic, heart enhance
and hemangiectasis therapy. Fiberopticbronchoscopy was used at least 1 times per day, the frequency could be increased if patients'
sputumwas too much. Patients in control group only received classic therapy. The heart index, respiratory rate, arterial blood gas analysis
and serum brain natriuretic peptide level at 72h after treatment were measured and compared between two groups.Results:At 1h after
treatment, the heart index of patients in control group increased from (2.7± 0.2) L/min·m2 to (3.1± 0.3) L/min·m2, the respiratory rate
decreased from 35.4± 2.9 times per min to 21.3± 2.5 times per min, the PaO2 increased from 57.4± 3.9 mmHg to 60.3± 3.4 mmHg, the
SaO2 increased from(83.5± 7.1)%to (86.3± 3.7)%, and the differences were statistically significant(P<0.05); while the heart index of patients
in study group increased from(2.8± 0.1) L/min·m2 to (3.5± 0.2) L/min·m2, the respiratory rate decreased from34.2± 3.1 times per
min to 19.2± 2.2 times per min, the PaO2 increased from 56.5± 4.8 mmHg to 66.2± 7.1 mmHg, the SaO2 increased from (84.5± 6.5)%
to (91.6± 3.5)%, and the differences were statistically significant(P<0.05). Moreover, the levels of index mentioned above were all better
in study group than those in the control group (P<0.05). The cough, expectoration and pulmonary moist rales significantly relieved in
79.2%of patients in study group within 24 h, while in control group, this percentage was 47.7%, which was obviously lower than that of
the study group (P<0.05). The serumBNP level of study group was much lower than that of the control group (576.3± 77.6 vs 894.6±
86.5, P<0.01) at 72 h after treatment.Conclusion:Sputum suction treatment by fiberoptic bronchoscopy was an efficient therapy in patients
with heart failure after pneumonectomy. |
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