| 潘琪 杨二姣 韩大芬 郑建华.TCT联合HPV检测诊断宫颈病变的临床价值分析[J].现代生物医学进展英文版,2015,15(1):80-83. |
| TCT联合HPV检测诊断宫颈病变的临床价值分析 |
| Analysis of the Clinical Value of TCT Combined with HPV Testingin the Diagnosis of Cervical Lesions |
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| DOI： |
| 中文关键词: 新柏氏液基细胞学技术 人乳头瘤病毒 宫颈病变 |
| 英文关键词: TCT HPV Cervical lesions |
| 基金项目:中华医学会分子生物学临床应用研究专项资金(CAMB022010)；国家自然科学基金项目(30973188) |
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| 中文摘要: |
| 目的：探讨新柏氏液基细胞学技术(TCT)联合人乳头瘤病毒(human papilloma virus，HPV)检测诊断宫颈病变的临床价值。方
法：选择哈尔滨医科大学附属第一医院妇科门诊收治的6752 例患者，采集其宫颈脱落细胞进行TCT检测，登记患者的年龄及宫
颈外观。分别随机选取TCT 阳性和阴性结果的患者144 例进行HPV 检测及阴道镜下活检，分析和比较TCT 单独及联合HPV 检
测诊断宫颈病变的敏感性和特异性。结果：宫颈柱状上皮细胞的外移程度及患者的年龄与宫颈TCT 结果均无显著相关性。单独
TCT检测诊断宫颈病变的灵敏度为87.04%，特异性为58.55%；单独HPV 检测诊断宫颈病变的灵敏度为62.96%，特异性为
81.62%；而联合测诊断宫颈病变的灵敏度为100%，特异度为48.29%。结论：TCT 联合HPV检测可显著降低宫颈病变的漏诊率。 |
| 英文摘要: |
| Objective:To study the clinical value of TCT combined with HPV testing in the diagnosis of cervical lesions.Methods:The desquamated cells of uterine tube of 6752 patients were collected in Harbin hospital and conducted the TCT test, while each patient's
age and uterine tube appearance were registered. 144 cases were selected from the positive and negative results of TCT randomly and
were examined by HPV and colposcopy biopsy, the sensitivity and specificity of TCT alone and combined with HPV detection in the diagnosis
of cervical lesion were analyzed and compared.Results:No significant correlation was found between the moving of cells in
columnar epithelium of the uterine tube and uterine tube TCT result. Moreover, no obvious correlation was found between the age and
TCT result of uterine tube. The sensitivity and specificity of TCT test alone were 87.04% and 58.55% respectively, which were 62.96%
and 81.62% of HPV test alone, 100%and 48.29% of TCT combined with HPV test in the diagnosis of cervical lesion.Conclusion:TCT
combined with HPV detection could significantky lower the rate of missed diagnosis in the diagnosis of cervical lesions. |
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