| 陈岩 郑玉玲 战莹 秦庚 吴琼.Nano-SiO2对子代雌性小鼠动情周期的影响[J].现代生物医学进展英文版,2015,15(1):18-20. |
| Nano-SiO2对子代雌性小鼠动情周期的影响 |
| The Effects of Nano-SiO2 on the Estrous Cycle of Offspring Female Mice |
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| DOI： |
| 中文关键词: 纳米二氧化硅 动情周期 子代雌鼠 |
| 英文关键词: Nano-SiO2 Estrous Cycle Offspring female mice |
| 基金项目:黑龙江省自然科学基金项目（C201217）；哈尔滨工业大学城市水资源与水环境国家重点实验室自主课题（2013DX07） |
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| 中文摘要: |
| 目的：探讨纳米二氧化硅(Nano-SiO2)对子代雌性小鼠动情周期的影响。方法：选择8 周龄的ICR 孕鼠6 只，随机平均分为两
组，一组在E5.5~E11.5 时隔天注射纳米二氧化硅，另外一组注射PBS，每组取子代雌性小鼠各3 只，待其自然生长到7 周龄时，每
日采用巴氏染色法检查其动情周期。结果：与注射PBS 的子代雌性小鼠相比，注射Nano-SiO2的子代雌性小鼠的动情周期的总时
间无明显差异(P>0.05)，动情前期的时间明显缩短，动情后期的时间明显延长(P<0.05)，动情期虽然缩短，但差异不显著(P>0.05)。
结论：孕期暴露于Nano-SiO2未导致子代雌性小鼠动情周期的紊乱，但对其生殖功能可能有一定的影响。 |
| 英文摘要: |
| Objective:To study the effects of nano silica (Nano-SiO2) on the estrous cycle of female mice.Methods:Six ICR pregnant
rats at 8 weeks were selected and randomly divided into two groups: one group was injected with nano silica in E5.5-E11.5 every
other day, while the other group was injected with PBS. Three offspring female mice were taken daily by PAP staining examination of
the estrous cycle in each group when they grow up to 7 weeks were.Results:Injection of Nano - SiO2 of offspring female mice compared
with injection of PBS of offspring female mice, there were no significant differences in total time of the estrous cycle of offspring female
mice (P>0.05); proestrus time was significantly shorter and metestrus time was significantly prolonged (P<0.05); although the estrous period
was shortened, but the difference was not significant (P>0.05).Conclusion:Prenatal exposure to Nano-SiO2 did not result in offspring
female mice estrous cycle disorder, but may have a certain influence on the reproductive function. |
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