| 殷润婷1 杨阳1 张婕1 葛雪梅2△ 张伟.固体脂质纳米粒的制备及在治疗中的应用研究[J].现代生物医学进展英文版,2014,14(36):7182-7185. |
| 固体脂质纳米粒的制备及在治疗中的应用研究 |
| The Preparation of Solid Lipid Nanoparticles and Its Application inTherapeuticals |
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| DOI： |
| 中文关键词: 固体脂质纳米粒 特点 应用 纳米结构脂质载体 |
| 英文关键词: SLN Characteristics Application NLC |
| 基金项目:江苏省自然科学青年基金项目(81402189)；国家自然科学基金项目（81070197）；江苏省高校优势学科发展项目 |
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| 中文摘要: |
| ：固体脂质纳米粒（SLN)是20 世纪90年代发展起来的一种性能优异的新型纳米粒给药剂型作为一种新型载体, 可有效提高
包封药物的稳定性、提高病变部位靶向性、低毒性与组织亲和性，为药物的体内递送提供了一种新的方法。本文主要针对固体脂
质纳米粒的制备,发展现状，目前存在的问题及解决思路等作以介绍与总结。并在此基础上，介绍了新的脂质纳米粒，纳米脂质载
体（nanostructured lipid carriers，NLC）和药脂结合物纳米粒(Lipid drug conjugate nanoparticles，LDC)，以及未来固体脂质纳米粒的
发展方向。 |
| 英文摘要: |
| Solid lipid nanoparticles (SLN) is an excellent new nanoparticles drug delivery systemwhich developed rapidly since
1990s. As a new vector, solid lipid nanoparticles may improve the stability of the encapsulated drugs, enhance targeting efficiency to the
diseased site, low toxicity and biocompatibility. It has provided a promising method for drug delivery. This paper reviewed the
preparation, development, the problems and solution in its application of the SLN nano-carriers. Based on previous study, nanostructured
lipid carriers (NLC) and lipid drug conjugated nanoparticles (LDC) and the development of the solid lipid nanoparticles were also
introduced in this artcle. |
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